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Network connectivity determines cortical thinning in early Parkinson's disease progression.
Yau, Y; Zeighami, Y; Baker, T E; Larcher, K; Vainik, U; Dadar, M; Fonov, V S; Hagmann, P; Griffa, A; Misic, B; Collins, D L; Dagher, A.
Afiliación
  • Yau Y; Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC, H3A 2B4, Canada.
  • Zeighami Y; Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC, H3A 2B4, Canada.
  • Baker TE; Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC, H3A 2B4, Canada.
  • Larcher K; Center for Molecular and Behavioral Neuroscience, Rutgers University, 197 University Avenue, Newark, NJ, 07102, USA.
  • Vainik U; Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC, H3A 2B4, Canada.
  • Dadar M; Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC, H3A 2B4, Canada.
  • Fonov VS; Institute of Psychology, Faculty of Social Sciences, University of Tartu, Näituse 2, 50409, Tartu, Estonia.
  • Hagmann P; Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC, H3A 2B4, Canada.
  • Griffa A; Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC, H3A 2B4, Canada.
  • Misic B; Department of Radiology, Lausanne University Hospital and University of Lausanne, Rue du Bugnon 21, 1011, Lausanne, Switzerland.
  • Collins DL; Brain Center Rudolf Magnus, UMC Utrecht, Heidelberglaan 100, A01.126, 3508 GA, Utrecht, The Netherlands.
  • Dagher A; Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC, H3A 2B4, Canada.
Nat Commun ; 9(1): 12, 2018 01 02.
Article en En | MEDLINE | ID: mdl-29295991
Here we test the hypothesis that the neurodegenerative process in Parkinson's disease (PD) moves stereotypically along neural networks, possibly reflecting the spread of toxic alpha-synuclein molecules. PD patients (n = 105) and matched controls (n = 57) underwent T1-MRI at entry and 1 year later as part of the Parkinson's Progression Markers Initiative. Over this period, PD patients demonstrate significantly greater cortical thinning than controls in parts of the left occipital and bilateral frontal lobes and right somatomotor-sensory cortex. Cortical thinning is correlated to connectivity (measured functionally or structurally) to a "disease reservoir" evaluated by MRI at baseline. The atrophy pattern in the ventral frontal lobes resembles one described in certain cases of Alzheimer's disease. Our findings suggest that disease propagation to the cortex in PD follows neuronal connectivity and that disease spread to the cortex may herald the onset of cognitive impairment.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Corteza Cerebral / Conectoma Tipo de estudio: Clinical_trials / Etiology_studies / Observational_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2018 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Corteza Cerebral / Conectoma Tipo de estudio: Clinical_trials / Etiology_studies / Observational_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2018 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Reino Unido