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Skin derived precursor Schwann cell-generated acellular matrix modified chitosan/silk scaffolds for bridging rat sciatic nerve gap.
Zhu, Changlai; Huang, Jing; Xue, Chengbin; Wang, Yaxian; Wang, Shengran; Bao, Shuangxi; Chen, Ruyue; Li, Yuan; Gu, Yun.
Afiliación
  • Zhu C; Jiangsu Key Laboratory of Neuroregeneration, Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair, Co-innovation Center of Neuroregeneration, Nantong University, 19 Qixiu Road, Nantong, JS, 226001, China.
  • Huang J; Jiangsu Key Laboratory of Neuroregeneration, Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair, Co-innovation Center of Neuroregeneration, Nantong University, 19 Qixiu Road, Nantong, JS, 226001, China.
  • Xue C; Jiangsu Key Laboratory of Neuroregeneration, Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair, Co-innovation Center of Neuroregeneration, Nantong University, 19 Qixiu Road, Nantong, JS, 226001, China.
  • Wang Y; Jiangsu Key Laboratory of Neuroregeneration, Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair, Co-innovation Center of Neuroregeneration, Nantong University, 19 Qixiu Road, Nantong, JS, 226001, China.
  • Wang S; Jiangsu Key Laboratory of Neuroregeneration, Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair, Co-innovation Center of Neuroregeneration, Nantong University, 19 Qixiu Road, Nantong, JS, 226001, China.
  • Bao S; Jiangsu Key Laboratory of Neuroregeneration, Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair, Co-innovation Center of Neuroregeneration, Nantong University, 19 Qixiu Road, Nantong, JS, 226001, China.
  • Chen R; Jiangsu Key Laboratory of Neuroregeneration, Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair, Co-innovation Center of Neuroregeneration, Nantong University, 19 Qixiu Road, Nantong, JS, 226001, China.
  • Li Y; Jiangsu Key Laboratory of Neuroregeneration, Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair, Co-innovation Center of Neuroregeneration, Nantong University, 19 Qixiu Road, Nantong, JS, 226001, China.
  • Gu Y; Jiangsu Key Laboratory of Neuroregeneration, Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair, Co-innovation Center of Neuroregeneration, Nantong University, 19 Qixiu Road, Nantong, JS, 226001, China. Electronic address: guyun@ntu.edu.cn.
Neurosci Res ; 135: 21-31, 2018 Oct.
Article en En | MEDLINE | ID: mdl-29288689
Extracellular/acellular matrix has been attracted much research interests for its unique biological characteristics, and ACM modified neural scaffolds shows the remarkable role of promoting peripheral nerve regeneration. In this study, skin-derived precursors pre-differentiated into Schwann cells (SKP-SCs) were used as parent cells to generate acellular(ACM) for constructing a ACM-modified neural scaffold. SKP-SCs were co-cultured with chitosan nerve guidance conduits (NGC) and silk fibroin filamentous fillers, followed by decellularization to stimulate ACM deposition. This NGC-based, SKP-SC-derived ACM-modified neural scaffold was used for bridging a 10 mm long rat sciatic nerve gap. Histological and functional evaluation after grafting demonstrated that regenerative outcomes achieved by this engineered neural scaffold were better than those achieved by a plain chitosan-silk fibroin scaffold, and suggested the benefits of SKP-SC-derived ACM for peripheral nerve repair.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células de Schwann / Nervio Ciático / Quitosano / Andamios del Tejido / Traumatismos de los Nervios Periféricos / Fibroínas / Dermis Acelular / Tratamiento Basado en Trasplante de Células y Tejidos Límite: Animals Idioma: En Revista: Neurosci Res Asunto de la revista: NEUROLOGIA Año: 2018 Tipo del documento: Article País de afiliación: China Pais de publicación: Irlanda
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células de Schwann / Nervio Ciático / Quitosano / Andamios del Tejido / Traumatismos de los Nervios Periféricos / Fibroínas / Dermis Acelular / Tratamiento Basado en Trasplante de Células y Tejidos Límite: Animals Idioma: En Revista: Neurosci Res Asunto de la revista: NEUROLOGIA Año: 2018 Tipo del documento: Article País de afiliación: China Pais de publicación: Irlanda