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Outbreaks of acute gastroenteritis associated with a re-emerging GII.P16-GII.2 norovirus in the spring of 2017 in Jiangsu, China.
Fu, Jian-Guang; Shi, Chao; Xu, Cheng; Lin, Qin; Zhang, Jun; Yi, Qian-Hua; Zhang, Jun; Bao, Chang-Jun; Huo, Xiang; Zhu, Ye-Fei; Ai, Jing; Xing, Zheng.
Afiliación
  • Fu JG; Medical School and Jiangsu Key Laboratory of Molecular Medicine, Nanjing University, Nanjing, China.
  • Shi C; Key Lab of Enteric Pathogenic Microbiology, Ministry of Health, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, China.
  • Xu C; Wuxi Center for Disease Control and Prevention, Wuxi, China.
  • Lin Q; The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China.
  • Zhang J; Changzhou Center for Disease Control and Prevention, Changzhou, China.
  • Yi QH; Yangzhou Center for Disease Control and Prevention, Yangzhou, China.
  • Zhang J; Taizhou Center for Disease Control and Prevention, Taizhou, China.
  • Bao CJ; Suzhou Center for Disease Control and Prevention, Suzhou, China.
  • Huo X; Key Lab of Enteric Pathogenic Microbiology, Ministry of Health, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, China.
  • Zhu YF; Key Lab of Enteric Pathogenic Microbiology, Ministry of Health, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, China.
  • Ai J; The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China.
  • Xing Z; Key Lab of Enteric Pathogenic Microbiology, Ministry of Health, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, China.
PLoS One ; 12(12): e0186090, 2017.
Article en En | MEDLINE | ID: mdl-29284004
A total of 64 acute gastroenteritis outbreaks with 2,953 patients starting in December of 2016 and occurring mostly in the late spring of 2017 were reported in Jiangsu, China. A recombinant GII.P16-GII.2 norovirus variant was associated with 47 outbreaks (73.4%) for the gastroenteritis epidemic, predominantly occurring in February and March of 2017. Sequence analysis of the RNA-dependent RNA polymerase (RdRp) and capsid protein of the viral isolates from these outbreaks confirmed that this GII.P16-GII.2 strain was the GII.P16-GII.2 variant with the intergenotypic recombination, identified in Taiwan, Hong Kong, and other cities in China in 2016. This GII.P16-GII.2 recombinant variant appeared to a re-emerging strain, firstly identified in 2011-2012 from Japan and USA but might be independently originated from other GII.P16-GII.2 variants for sporadic and outbreaks of gastroenteritis in Japan and China before 2016. Further identification of unique amino acid mutations in both VP1 and RdRp of NoV strain as shown in this report may provide insight in explaining its structural and antigenic changes, potentially critical for the variant recombinant to gain its predominance in causing regional and worldwide epidemics.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Brotes de Enfermedades / Infecciones por Caliciviridae / Norovirus / Gastroenteritis Tipo de estudio: Risk_factors_studies Límite: Humans País/Región como asunto: Asia Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2017 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Brotes de Enfermedades / Infecciones por Caliciviridae / Norovirus / Gastroenteritis Tipo de estudio: Risk_factors_studies Límite: Humans País/Región como asunto: Asia Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2017 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos