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Role of Full-spectrum Endoscopy in Colorectal Cancer Screening: Randomized Trial.
Núñez-Rodríguez, Henar; Diez-Redondo, Pilar; Pérez-Miranda, Manuel; Gonzalez Sagrado, Manuel; Conde, Rosa; De la Serna, Carlos.
Afiliación
  • Núñez-Rodríguez H; Gastroenterology Department.
  • Diez-Redondo P; Gastroenterology Department.
  • Pérez-Miranda M; Gastroenterology Department.
  • Gonzalez Sagrado M; Investigation Department, Rio Hortega Hospital.
  • Conde R; Investigation Department, Rio Hortega Hospital.
  • De la Serna C; Gastroenterology Department, University Rio Hortega Hospital, Valladolid, Spain.
J Clin Gastroenterol ; 53(3): 191-196, 2019 03.
Article en En | MEDLINE | ID: mdl-29283904
GOALS: The aim of this study was to compare a new, full-spectrum endoscope (Fuse; EndoChoice, Alpharetta, GA) to standard forward-viewing colonoscopy in the detection of colorectal neoplasms. BACKGROUND: Colonoscopy, the gold standard for the detection of colorectal cancer, fails to detect 22% to 28% of polyps, increasing the risk of interval cancer. Endoscopic improvement of the adenoma detection rate decrease interval carcinomas. Full-spectrum endoscopy (FUSE) (330-degree field of view), in a tandem study, has been shown to reduce the adenoma miss rate. STUDY: Prospective, randomized study of 249 patients in patients referred from the colorectal screening program with a positive fecal occult blood test (FOBT). Patients were randomized to standard forward-viewing colonoscopy (170 degrees) or to full-spectrum colonoscopy with the Fuse system (330 degrees). Study variables were the adenoma detection rate, the polyp detection rate, the mean number of adenomas per procedure, the lesions detected according to the location, morphology and size, cecal intubation rate, total procedure time, insertion time to the cecum, therapeutic success, and adverse events. RESULTS: The Fuse system did not produce a significantly higher adenoma detection rate than standard forward-viewing colonoscopy (FUSE 73.1% vs. standard colonoscopy 68.1%; P=0.47) but did have a significantly longer insertion time (FUSE 6.2 min vs. standard colonoscopy 4.2 min; P< 0.001). Further analysis failed to reveal any significant difference in polyp/adenoma detection rates by lesion size or colonic section. CONCLUSIONS: FUSE did not detect significantly more colorectal neoplasia than forward viewing colonoscopy in a medium-risk CRC screening population with positive FOBT.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Adenoma / Colonoscopía Tipo de estudio: Clinical_trials / Diagnostic_studies / Observational_studies / Screening_studies Límite: Female / Humans / Male / Middle aged Idioma: En Revista: J Clin Gastroenterol Año: 2019 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Adenoma / Colonoscopía Tipo de estudio: Clinical_trials / Diagnostic_studies / Observational_studies / Screening_studies Límite: Female / Humans / Male / Middle aged Idioma: En Revista: J Clin Gastroenterol Año: 2019 Tipo del documento: Article Pais de publicación: Estados Unidos