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Inhibition of Formation of Azoxymethane-induced Colonic Aberrant Crypt Foci in Rats by Edible Green Algae Capsosiphon fulvescens and Brown Algae Hizikia fusiforme.
Son, Young-Sook; Ullah, H M Arif; Elfadl, Ahmed K; Ghim, Soong-Gu; Chung, Myung-Jin; Kim, Yong Deuk; Lee, Eun-Joo; Kang, Kyung-Ku; Jeong, Kyu-Shik.
Afiliación
  • Son YS; College of Veterinary Medicine and Stem Cell Therapeutic Research Institute, Kyungpook National University, Daegu, Republic of Korea.
  • Ullah HMA; College of Veterinary Medicine and Stem Cell Therapeutic Research Institute, Kyungpook National University, Daegu, Republic of Korea.
  • Elfadl AK; College of Veterinary Medicine and Stem Cell Therapeutic Research Institute, Kyungpook National University, Daegu, Republic of Korea.
  • Ghim SG; College of Veterinary Medicine and Stem Cell Therapeutic Research Institute, Kyungpook National University, Daegu, Republic of Korea.
  • Chung MJ; College of Veterinary Medicine and Stem Cell Therapeutic Research Institute, Kyungpook National University, Daegu, Republic of Korea.
  • Kim YD; College of Veterinary Medicine and Stem Cell Therapeutic Research Institute, Kyungpook National University, Daegu, Republic of Korea.
  • Lee EJ; College of Veterinary Medicine and Stem Cell Therapeutic Research Institute, Kyungpook National University, Daegu, Republic of Korea.
  • Kang KK; College of Veterinary Medicine and Stem Cell Therapeutic Research Institute, Kyungpook National University, Daegu, Republic of Korea.
  • Jeong KS; College of Veterinary Medicine and Stem Cell Therapeutic Research Institute, Kyungpook National University, Daegu, Republic of Korea jeongks@knu.ac.kr.
In Vivo ; 32(1): 101-108, 2018.
Article en En | MEDLINE | ID: mdl-29275305
Capsosiphon fulvescens (green seaweed) and Hizikia fusiforme (brown seaweed) are marine algae consumed as food supplements, especially in Japan, China and Korea, and are considered traditional medicinal tonics for certain ailments. The aim of this study was to investigate the possible inhibitory effects of dietary C. fulvescens and H. fusiforme on azoxymethane (AOM)-induced colorectal cancer (CRC) in rats. F344 male rats (5 weeks, 150 g) were divided into six groups as follows. Group 1: Injected with normal saline solution and fed control diet (untreated control). Group 2: Injected with AOM and fed control diet (treated control). Group 3: Injected with AOM and fed 1% C. fulvescens diet. Group 4: Injected with AOM and fed 2% C. fulvescens diet. Group 5: Injected with AOM and fed 2% H. fusiforme diet. Group 6: Injected with AOM and fed 6% H. fusiforme diet. Test animals received subcutaneous injections of AOM (15 mg/1 ml/kg body weight) once a week for 2 weeks to induce aberrant crypt foci (ACF) in treated control and experimental groups. We evaluated the effects of dietary C. fulvescens and H. fusiforme at two different dose levels: 1 and 2% C. fulvescens, and 2 and 6% H. fusiforme, on colonic carcinogenesis by AOM in rats. Our results suggest that body weights were not significantly different amongst groups. We found that feeding C. fulvescens and H. fusiforme with a control diet significantly (p<0.05) inhibited the development of ACF in experimental groups. C. fulvescens and H. fusiforme in food also significantly (p<0.05) reduced the proliferating cell nuclear antigen labeling index in the colonic tissues of experimental groups. These results demonstrate the chemopreventive potential of C. fulvescens and H. fusiforme against CRC in an AOM-induced rats.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Productos Biológicos / Neoplasias del Colon / Phaeophyceae / Chlorophyta / Focos de Criptas Aberrantes Límite: Animals Idioma: En Revista: In Vivo Asunto de la revista: NEOPLASIAS Año: 2018 Tipo del documento: Article Pais de publicación: Grecia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Productos Biológicos / Neoplasias del Colon / Phaeophyceae / Chlorophyta / Focos de Criptas Aberrantes Límite: Animals Idioma: En Revista: In Vivo Asunto de la revista: NEOPLASIAS Año: 2018 Tipo del documento: Article Pais de publicación: Grecia