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Performance of two immunochromatographic tests for diagnosis of visceral leishmaniasis in patients coinfected with HIV.
da Silva, Mauro Roberto Biá; Brandão, Natália Alberto Alves; Colovati, Marco; de Sousa, Margella Marconcine Pinheiro; de Lima, Larissa Coelho; Dorta, Miriam Leandro; Ribeiro-Dias, Fátima; Costa, Dorcas Lamounier; Costa, Carlos Henrique Nery; de Oliveira, Milton Adriano Pelli.
Afiliación
  • da Silva MRB; Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás, Rua 235 S/N - Setor Universitário, Goiânia, GO, 74605-050, Brazil.
  • Brandão NAA; Instituto de Doenças Tropicais Natan Portela, R. Artur de Vasconcelos 151-Sul, Teresina, PI, 64001-450, Brazil.
  • Colovati M; Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás, Rua 235 S/N - Setor Universitário, Goiânia, GO, 74605-050, Brazil.
  • de Sousa MMP; OrangeLife Comércio e Indústria LTDA, Est Dos Bandeirantes, 11742, Parte, Vargem Pequena, Rio De Janeiro, RJ, 22783-111, Brazil.
  • de Lima LC; OrangeLife Comércio e Indústria LTDA, Est Dos Bandeirantes, 11742, Parte, Vargem Pequena, Rio De Janeiro, RJ, 22783-111, Brazil.
  • Dorta ML; OrangeLife Comércio e Indústria LTDA, Est Dos Bandeirantes, 11742, Parte, Vargem Pequena, Rio De Janeiro, RJ, 22783-111, Brazil.
  • Ribeiro-Dias F; Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás, Rua 235 S/N - Setor Universitário, Goiânia, GO, 74605-050, Brazil.
  • Costa DL; Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás, Rua 235 S/N - Setor Universitário, Goiânia, GO, 74605-050, Brazil.
  • Costa CHN; Instituto de Doenças Tropicais Natan Portela, R. Artur de Vasconcelos 151-Sul, Teresina, PI, 64001-450, Brazil.
  • de Oliveira MAP; Instituto de Doenças Tropicais Natan Portela, R. Artur de Vasconcelos 151-Sul, Teresina, PI, 64001-450, Brazil.
Parasitol Res ; 117(2): 419-427, 2018 Feb.
Article en En | MEDLINE | ID: mdl-29270768
Because of visceral leishmaniasis (VL) urbanization and spreading of the human immunodeficiency virus (HIV) infection to rural areas, coinfection has become more common. Here, we compared the accuracy of Kalazar Detect® (KD), an rK39-based immunochromatographic (IC) test, and OrangeLife® (OL), an rK39 + rK28 IC test, for diagnosing VL in patients coinfected with HIV in an endemic area in Brazil. Seventy-six VL patients and 40 patients with other diseases, of which 31 and 21 patients, respectively, were infected with HIV, were examined. The sensitivity of OL and KD tests was 88.89 and 95.45%, respectively, in patients without HIV. The sensitivity dropped to 67.74 and 61.29%, respectively, in coinfected patients. The decrease in sensitivity was not related to a decrease in the production of Leishmania-specific IgG. Because of the low sensitivity of rk39 test in HIV-infected patients, we suggest that patients with negative rK39 results should undergo further investigation with additional serological tests that are not based only on the rK39 antigen and examination of bone marrow aspirates.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por VIH / Cromatografía de Afinidad / Leishmaniasis Visceral Tipo de estudio: Diagnostic_studies / Evaluation_studies Límite: Adult / Female / Humans / Male País/Región como asunto: America do sul / Brasil Idioma: En Revista: Parasitol Res Asunto de la revista: PARASITOLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por VIH / Cromatografía de Afinidad / Leishmaniasis Visceral Tipo de estudio: Diagnostic_studies / Evaluation_studies Límite: Adult / Female / Humans / Male País/Región como asunto: America do sul / Brasil Idioma: En Revista: Parasitol Res Asunto de la revista: PARASITOLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Alemania