Your browser doesn't support javascript.
loading
Look into hepatic progenitor cell associated trait: Histological heterogeneity of hepatitis B-related combined hepatocellular-cholangiocarcinoma.
Cai, Xiong; Xiong, Jun; Hu, Qing-Gang; Zhao, Qiu-Dong; Wu, Dong; Tang, Li-Gong; Wan, Chi-Dan; Wei, Li-Xin.
Afiliación
  • Cai X; Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
  • Xiong J; Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
  • Hu QG; Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
  • Zhao QD; Tumor Immunology and Gene Therapy Center, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, 200438, China.
  • Wu D; Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, 200438, China.
  • Tang LG; Department of Urology, Wuhan General Hospital of PLA, Wuhan, 430070, China.
  • Wan CD; Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. chidanwan@163.com.
  • Wei LX; Tumor Immunology and Gene Therapy Center, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, 200438, China. weilixin_smmu@163.com.
J Huazhong Univ Sci Technolog Med Sci ; 37(6): 873-879, 2017 Dec.
Article en En | MEDLINE | ID: mdl-29270746
Combined hepatocellular-cholangiocarcinoma (CHC) is a mixed tumor containing elements of both hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC). Its remarkable histological heterogeneity has been linked to putative hepatic progenitor cell (HPC) origin. However, detailed histological or phenotypic description is rarely documented. In the present study, we reassessed 68 cases previously diagnosed as hepatitis B-related CHCs by immunohistochemistry and double-fluorescence immunostaining, focusing on HPC associated phenotypic observation of intermediate area of the tumor. It was found that tumor cells showed remarkable heterogeneity in intermediate area. Tumor cells with intermediate morphology between hepatocytes and cholangiocytes were oval-shaped and small with scant cytoplasm and hyperchromatic nuclei, arranging in solid nests mostly. By Keratin 7 (K7) staining, it appeared that the nests of tumor cells represented a maturation process from the undifferentiated small cells to mature hepatocytes through the "transitional" cells. Then, these small cells were further confirmed with intermediate phenotype as HPC by exploring immature hepatocellular marker and HPC/biliary markers co-localization. In conclusion, the HPC associated trait in CHC can be interpreted by HPC origin or gain of "stemness" by dedifferentiation. It is still too soon to give a final word that it is innate or acquired signature of HPC associated trait in CHC.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de los Conductos Biliares / Biomarcadores de Tumor / Colangiocarcinoma / Carcinoma Hepatocelular / Hepatitis B / Neoplasias Hepáticas Tipo de estudio: Observational_studies / Risk_factors_studies Idioma: En Revista: J Huazhong Univ Sci Technolog Med Sci Asunto de la revista: MEDICINA Año: 2017 Tipo del documento: Article País de afiliación: China Pais de publicación: China
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de los Conductos Biliares / Biomarcadores de Tumor / Colangiocarcinoma / Carcinoma Hepatocelular / Hepatitis B / Neoplasias Hepáticas Tipo de estudio: Observational_studies / Risk_factors_studies Idioma: En Revista: J Huazhong Univ Sci Technolog Med Sci Asunto de la revista: MEDICINA Año: 2017 Tipo del documento: Article País de afiliación: China Pais de publicación: China