Your browser doesn't support javascript.
loading
Polychlorinated biphenyls, indicators of thyroid function and thyroid autoantibodies in the Anniston Community Health Survey I (ACHS-I).
Benson, Kelsey; Yang, Eric; Dutton, Nina; Sjodin, Andreas; Rosenbaum, Paula F; Pavuk, Marian.
Afiliación
  • Benson K; Agency for Toxic Substances and Disease Registry (ATSDR), Atlanta, GA, USA. Electronic address: yrn0@cdc.gov.
  • Yang E; Oak Ridge Institute for Science and Education (ORISE), USA.
  • Dutton N; Oak Ridge Institute for Science and Education (ORISE), USA.
  • Sjodin A; Division of Laboratory Sciences, National Center for Environmental Health (NCEH), Atlanta, GA, USA.
  • Rosenbaum PF; Department of Public Health & Preventive Medicine, State University of New York (SUNY) Upstate Medical University, Syracuse, NY, USA.
  • Pavuk M; Agency for Toxic Substances and Disease Registry (ATSDR), Atlanta, GA, USA.
Chemosphere ; 195: 156-165, 2018 Mar.
Article en En | MEDLINE | ID: mdl-29268174
In this study, we examined associations between serum concentrations of 35 polychlorinated biphenyl (PCB) congeners, pesticides, and indicators of thyroid function in participants of the Anniston Community Health Survey (ACHS). Study subjects lived in the vicinity of a former PCB production facility and had PCB concentrations 2 to 3 times higher than similar age and race groups from the general population. We investigated associations among serum levels of thyroid hormones (thyroxin [T4], free thyroxin [fT4], triiodothyronine [T3], thyroid stimulation hormone [TSH]) and auto-antibodies (thyroglobulin antibody [TgAb] or thyroperoxidase antibody [TPOAb]) and combined indicators of thyroid function with the sum of PCBs, varying PCB groups, individual PCB congeners, and 8 pesticides. Logistic and linear regression models were adjusted for log10 transformed total lipids, age, sex, ethnicity, BMI, smoking, and family history of thyroid disease. We also performed analyses stratified by ethnicity and sex. Linear regression showed inverse associations between TT3 and thyroid-like PCBs (sum of PCBs 28, 52, 74, 101, 105, and 118; p = .0004), two pesticides (hexachlorobenzene, and pp'-DDE), and individual congeners (PCBs 74, 105). Null associations were observed between PCBs, pesticides, TSH, TT4, and fT4. Logistic regression analyses did not provide support for TT3 findings and found no association with other thyroid hormones, antibodies, or combined indicator of thyroid function. These results suggest there is little evidence that these chemicals have any major clinical effect on thyroid function in this highly PCB exposed population.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glándula Tiroides / Hormonas Tiroideas / Encuestas Epidemiológicas / Bifenilos Policlorados / Exposición a Riesgos Ambientales Tipo de estudio: Prognostic_studies Límite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Chemosphere Año: 2018 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glándula Tiroides / Hormonas Tiroideas / Encuestas Epidemiológicas / Bifenilos Policlorados / Exposición a Riesgos Ambientales Tipo de estudio: Prognostic_studies Límite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Chemosphere Año: 2018 Tipo del documento: Article Pais de publicación: Reino Unido