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Survival outcome among patients with Ewing's sarcoma of bones and joints: a population-based cohort study.
Wan, Zi-Hao; Huang, Zhi-Hao; Chen, Liao-Bin.
Afiliación
  • Wan ZH; MD, MSc. Surgeon, Department of Orthopedic Surgery, Zhongnan Hospital, Wuhan University, Wuhan, Hubei Province, China.
  • Huang ZH; MD, MSc. Surgeon, Department of Colorectal and Anal Surgery, Zhongnan Hospital, Wuhan University, Wuhan, Hubei Province, China.
  • Chen LB; MD. Surgeon, Department of Orthopedic Surgery, Zhongnan Hospital, Wuhan University, Wuhan, Hubei Province, China.
Sao Paulo Med J ; 136(2): 116-122, 2018.
Article en En | MEDLINE | ID: mdl-29267540
BACKGROUND: The aim here was to elucidate the current survival condition of patients diagnosed with Ewing's sarcoma of the bones and joints and determine independent risk factors associated with the prognosis. DESIGN AND SETTING: Retrospective cohort study based on the Surveillance, Epidemiology and End Results (SEER) database in the United States. METHODS: We identified 397 patients who were diagnosed with Ewing's sarcoma of the bones and joints between January 2004 and December 2013. The multivariate Cox proportional hazards model was used to determine factors associated with the risk of death by adjusting for various factors. RESULTS: The one, two and five-year disease-specific survival rates were 89.08%, 78.08% and 62.47%, respectively. The factors related to death were age (≥ 18 years versus < 18 years; hazard ratio, HR = 1.77; 95% confidence interval, CI: 1.38-2.31); tumor site (extremity versus spine and pelvis; HR = 2.03; 95% CI: 1.31-2.62); tumor size (> 10 cm versus ≤ 10 cm; HR = 1.78; 95% CI: 1.34-2.56); and type of treatment (surgery alone versus radiotherapy with surgery; HR = 0.51; 95% CI: 0.38-0.89; or radiotherapy alone versus radiotherapy with surgery; HR = 1.61; 95% CI: 1.10-2.39; or no treatment versus radiotherapy with surgery; HR = 1.86; 95% CI: 1.23, 2.58). CONCLUSIONS: Patients with Ewing's sarcoma showed poor survival in situations of age ≥ 18 years, tumor size > 10 cm, receiving radiotherapy alone and receiving no treatment. Patients undergoing surgery alone had better survival.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sarcoma de Ewing / Neoplasias Óseas Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Female / Humans / Male País/Región como asunto: America do sul / Brasil Idioma: En Revista: Sao Paulo Med J Asunto de la revista: MEDICINA Año: 2018 Tipo del documento: Article País de afiliación: China Pais de publicación: Brasil
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sarcoma de Ewing / Neoplasias Óseas Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Female / Humans / Male País/Región como asunto: America do sul / Brasil Idioma: En Revista: Sao Paulo Med J Asunto de la revista: MEDICINA Año: 2018 Tipo del documento: Article País de afiliación: China Pais de publicación: Brasil