Parasite-Mediated Degradation of Synthetic Ozonide Antimalarials Impacts <i>In Vitro</i> Antimalarial Activity.

Giannangelo, Carlo; Stingelin, Lukas; Yang, Tuo; Tilley, Leann; Charman, Susan A; Creek, Darren J

Parasite-Mediated Degradation of Synthetic Ozonide Antimalarials Impacts In Vitro Antimalarial Activity.

Giannangelo, Carlo; Stingelin, Lukas; Yang, Tuo; Tilley, Leann; Charman, Susan A; Creek, Darren J.

Afiliación

Giannangelo C; Monash Institute of Pharmaceutical Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
Stingelin L; Monash Institute of Pharmaceutical Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
Yang T; Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, Victoria, Australia.
Tilley L; Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, Victoria, Australia.
Charman SA; Monash Institute of Pharmaceutical Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia susan.charman@monash.edu darren.creek@monash.edu.
Creek DJ; Monash Institute of Pharmaceutical Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia susan.charman@monash.edu darren.creek@monash.edu.

Antimicrob Agents Chemother ; 62(3)2018 03.

Article en En | MEDLINE | ID: mdl-29263074

Asunto(s)

Antimaláricos/farmacología; Compuestos Heterocíclicos/farmacología; Adamantano/análogos & derivados; Adamantano/farmacología; Antimaláricos/química; Eritrocitos/parasitología; Compuestos Heterocíclicos con 1 Anillo/farmacología; Humanos; Peróxidos/farmacología; Plasmodium falciparum/efectos de los fármacos; Compuestos de Espiro/farmacología; Trofozoítos/química

Palabras clave

Plasmodium falciparum; antimalarial activity; artefenomel; arterolane; ozonide; peroxide antimalarial; stability

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Compuestos Heterocíclicos / Antimaláricos Límite: Humans Idioma: En Revista: Antimicrob Agents Chemother Año: 2018 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Estados Unidos

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