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Pupillometry as an indicator of L-DOPA dosages in Parkinson's disease patients.
Bartosová, O; Bonnet, C; Ulmanová, O; Síma, M; Perlík, F; Ruzicka, E; Slanar, O.
Afiliación
  • Bartosová O; Department of Pharmacology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic. olga.matouskova@lf1.cuni.cz.
  • Bonnet C; Department of Neurology and Centre of Clinical Neuroscience, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.
  • Ulmanová O; Department of Neurology and Centre of Clinical Neuroscience, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.
  • Síma M; Department of Pharmacology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.
  • Perlík F; Department of Pharmacology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.
  • Ruzicka E; Department of Neurology and Centre of Clinical Neuroscience, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.
  • Slanar O; Department of Pharmacology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.
J Neural Transm (Vienna) ; 125(4): 699-703, 2018 04.
Article en En | MEDLINE | ID: mdl-29255941
Dopamine was shown to induce mydriasis by excitation of alpha-adrenergic receptors at the dilator pupillae muscle. Pupilla diameter may thus serve as an indirect measure of peripheral pharmacokinetics of L-DOPA and dopamine. The aim of this study is to evaluate the effect of L-DOPA dosage on pupillometric parameters in Parkinson's disease (PD) patients. Sixteen PD patients and 14 healthy control subjects (CS) were studied. The statistical analysis revealed significant differences between CS and PD patients for the mean maximum and minimum pupil diameters (p = 0.017, p = 0.028, respectively), with higher values found in PD. Moreover, a significant dose-response relationship was found between the maximum pupil diameter and both the morning L-DOPA dose (R 2 = 0.78) and the total daily L-DOPA dose (R 2 = 0.93). A sigmoid-shaped curve best describes the dose-response relationship, with a ceiling effect at about 400 mg L-DOPA daily dose. In conclusion, measuring pupillometric parameters represents a sensitive tool for non-invasive evaluation of the peripheral effect of L-DOPA, especially with daily doses below 400 mg L-DOPA.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Levodopa / Pupila / Antiparkinsonianos Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Neural Transm (Vienna) Año: 2018 Tipo del documento: Article País de afiliación: República Checa Pais de publicación: Austria
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Levodopa / Pupila / Antiparkinsonianos Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Neural Transm (Vienna) Año: 2018 Tipo del documento: Article País de afiliación: República Checa Pais de publicación: Austria