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Virulence patterns of Staphylococcus aureus strains from nasopharyngeal colonization.
Deinhardt-Emmer, S; Sachse, S; Geraci, J; Fischer, C; Kwetkat, A; Dawczynski, K; Tuchscherr, L; Löffler, B.
Afiliación
  • Deinhardt-Emmer S; Institute of Medical Microbiology, Jena University Hospital, Jena, Germany. Electronic address: stefanie.deinhardt-emmer@med.uni-jena.de.
  • Sachse S; Institute of Medical Microbiology, Jena University Hospital, Jena, Germany.
  • Geraci J; Institute of Medical Microbiology, Jena University Hospital, Jena, Germany.
  • Fischer C; Institute of Medical Microbiology, Jena University Hospital, Jena, Germany.
  • Kwetkat A; Department of Geriatric Medicine, Jena University Hospital, Jena, Germany.
  • Dawczynski K; Neonatology Unit, Department of Paediatrics, Jena University Hospital, Jena, Germany.
  • Tuchscherr L; Institute of Medical Microbiology, Jena University Hospital, Jena, Germany.
  • Löffler B; Institute of Medical Microbiology, Jena University Hospital, Jena, Germany; InfectoGnostics Forschungscampus Jena e.V., Zentrum für Angewandte Forschung, Jena, Germany.
J Hosp Infect ; 100(3): 309-315, 2018 Nov.
Article en En | MEDLINE | ID: mdl-29253623
BACKGROUND: The prevalence of nasopharyngeal colonization with Staphylococcus aureus can reach 20-30% among the population, which can lead to invasive infection. AIM: To investigate the prevalence of colonization among different age groups, and analyse S. aureus strain-specific virulence patterns. METHOD: For analysis of the prevalence of colonization, groups consisting of newborns, healthy volunteers aged 5-60 years, and nursing home residents aged >80 years were examined with nasopharyngeal swabs. After S. aureus was cultured, genetic analysis and phenotypic virulence testing were performed by cell-based assays. FINDINGS: Among 924 volunteers, the overall colonization rate was approximately 30%, with a peak in subjects aged 5-10 years (49%). Neonates and subjects aged >80 years showed different distributions of clonal clusters. Overall, the strains of all age groups exhibited virulence characteristics that can contribute to the development of infection. In particular, the neonatal strains exhibited a high incidence of toxin genes that resulted in increased cytotoxic effects compared with the other strains tested. CONCLUSIONS: Colonizing strains showed a virulence profile in all age groups, which may lead to the establishment of invasive infection. Consequently, decolonization measures could be considered for selected patients depending on the risk of infection.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones Estafilocócicas / Staphylococcus aureus / Portador Sano / Nasofaringe / Factores de Virulencia Tipo de estudio: Prevalence_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Aged80 / Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: J Hosp Infect Año: 2018 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones Estafilocócicas / Staphylococcus aureus / Portador Sano / Nasofaringe / Factores de Virulencia Tipo de estudio: Prevalence_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Aged80 / Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: J Hosp Infect Año: 2018 Tipo del documento: Article Pais de publicación: Reino Unido