The physical spacing between the von Willebrand factor D'D3 and A1 domains regulates platelet adhesion in vitro and in vivo.

Zhang, C; Kelkar, A; Nasirikenari, M; Lau, J T Y; Sveinsson, M; Sharma, U C; Pokharel, S; Neelamegham, S

The physical spacing between the von Willebrand factor D'D3 and A1 domains regulates platelet adhesion in vitro and in vivo.

Zhang, C; Kelkar, A; Nasirikenari, M; Lau, J T Y; Sveinsson, M; Sharma, U C; Pokharel, S; Neelamegham, S.

Afiliación

Zhang C; Department of Chemical and Biological Engineering, State University of New York, Buffalo, NY, USA.
Kelkar A; Clinical and Translational Research Center, State University of New York, Buffalo, NY, USA.
Nasirikenari M; Department of Chemical and Biological Engineering, State University of New York, Buffalo, NY, USA.
Lau JTY; Clinical and Translational Research Center, State University of New York, Buffalo, NY, USA.
Sveinsson M; Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, NY, USA.
Sharma UC; Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, NY, USA.
Pokharel S; Clinical and Translational Research Center, State University of New York, Buffalo, NY, USA.
Neelamegham S; Clinical and Translational Research Center, State University of New York, Buffalo, NY, USA.

J Thromb Haemost ; 16(3): 571-582, 2018 03.

Article en En | MEDLINE | ID: mdl-29251812

Asunto(s)

Plaquetas/citología; Adhesividad Plaquetaria; Pruebas de Función Plaquetaria; Dominios Proteicos; Factor de von Willebrand/metabolismo; Animales; ADN Complementario/metabolismo; Femenino; Células HEK293; Hemostasis; Humanos; Hidrodinámica; Masculino; Ratones; Microfluídica; Mucinas/química; Fenotipo; Activación Plaquetaria; Unión Proteica; Pliegue de Proteína; Ristocetina/química; Resistencia al Corte; Trombocitopenia/sangre; Trombosis/metabolismo

Palabras clave

blood platelets; hemodynamics; microfluidics; thrombosis; von Willebrand factor

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pruebas de Función Plaquetaria / Plaquetas / Factor de von Willebrand / Adhesividad Plaquetaria / Dominios Proteicos Límite: Animals / Female / Humans / Male Idioma: En Revista: J Thromb Haemost Asunto de la revista: HEMATOLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido

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