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Dissociation of biomolecules in liquid environments during fast heavy-ion irradiation.
Nomura, Shinji; Tsuchida, Hidetsugu; Kajiwara, Akihiro; Yoshida, Shintaro; Majima, Takuya; Saito, Manabu.
Afiliación
  • Nomura S; Department of Nuclear Engineering, Kyoto University, Nishikyo-ku, Kyoto 615-8530, Japan.
  • Tsuchida H; Department of Nuclear Engineering, Kyoto University, Nishikyo-ku, Kyoto 615-8530, Japan.
  • Kajiwara A; Department of Nuclear Engineering, Kyoto University, Nishikyo-ku, Kyoto 615-8530, Japan.
  • Yoshida S; Department of Nuclear Engineering, Kyoto University, Nishikyo-ku, Kyoto 615-8530, Japan.
  • Majima T; Department of Nuclear Engineering, Kyoto University, Nishikyo-ku, Kyoto 615-8530, Japan.
  • Saito M; Department of Nuclear Engineering, Kyoto University, Nishikyo-ku, Kyoto 615-8530, Japan.
J Chem Phys ; 147(22): 225103, 2017 Dec 14.
Article en En | MEDLINE | ID: mdl-29246061
The effect of aqueous environment on fast heavy-ion radiation damage of biomolecules was studied by comparative experiments using liquid- and gas-phase amino acid targets. Three types of amino acids with different chemical structures were used: glycine, proline, and hydroxyproline. Ion-induced reaction products were analyzed by time-of-flight secondary-ion mass spectrometry. The results showed that fragments from the amino acids resulting from the C-Cα bond cleavage were the major products for both types of targets. For liquid-phase targets, specific products originating from chemical reactions in solutions were observed. Interestingly, multiple dissociated atomic fragments were negligible for the liquid-phase targets. We found that the ratio of multifragment to total fragment ion yields was approximately half of that for gas-phase targets. This finding agreed with the results of other studies on biomolecular cluster targets. It is concluded that the suppression of molecular multifragmentation is caused by the energy dispersion to numerous water molecules surrounding the biomolecular solutes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Iones Pesados / Aminoácidos Idioma: En Revista: J Chem Phys Año: 2017 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Iones Pesados / Aminoácidos Idioma: En Revista: J Chem Phys Año: 2017 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos