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Analgesic efficacy of preoperative dexketoprofen trometamol: A systematic review and meta-analysis.
Esparza-Villalpando, Vicente; Pozos-Guillén, Amaury; Masuoka-Ito, David; Gaitán-Fonseca, César; Chavarría-Bolaños, Daniel.
Afiliación
  • Esparza-Villalpando V; Materials Engineering and Science Doctorate Program, Universidad Autónoma de San Luis Potosí, San Luis Potosí, SLP, México.
  • Pozos-Guillén A; Basic Sciences Laboratory, Universidad Autónoma de San Luis Potosí, San Luis Potosí, SLP, México.
  • Masuoka-Ito D; Stomatology Department, Universidad Autónoma de Aguascalientes, Aguascalientes, Ags. México.
  • Gaitán-Fonseca C; Maestría en Ciencias Biomédicas, Área Ciencias de la Salud, Universidad Autónoma de Zacatecas "Francisco García Salinas".
  • Chavarría-Bolaños D; Diagnostic and Surgical Sciences Department, Facultad de Odontología, Universidad de Costa Rica, Costa Rica.
Drug Dev Res ; 79(2): 47-57, 2018 03.
Article en En | MEDLINE | ID: mdl-29243848
Post-Market Research Clinical evidence supports the use of dexketoprofen trometamol (DEX) to manage acute postoperative pain. However, controversies surround the impact of the use of this drug in preoperative analgesic protocols. The aim of the present meta-analysis was to evaluate the effectiveness of the preoperative administration of DEX under postoperative pain conditions. Electronic and manual searches were conducted through diverse electronic databases. A systematic review and meta-analysis to evaluate the analgesic efficacy of the preoperative administration of DEX was performed including Randomized Clinical Trials (RCTs) published between 2002 and 2017. Suitable individual studies were evaluated through a quality system, and the data were extracted and analyzed. Fourteen RTCs were included (12 parallel trials and 2 cross-over trials), published in the English and Turkish languages. Follow-up periods ranged from 4, 6, 8, 24, and 48 hr. All trials measured the outcome result as Acute Pain Level (APL) (VAS, NRS, VRS), time to requiring a second dose of DEX or analgesic emergency and consumption of opioids via patient-controlled analgesia. When the comparators were other drugs - paracetamol, Lornoxicam or placebo during the preoperative time, preoperative administration of DEX was superior. When the comparison comprised preoperative and postoperative DEX, both alternatives exhibited comparable analgesic effects. The analgesic efficacy of the preoperative administration of DEX when compared to placebo, lornoxicam, and paracetamol on postoperative pain was evident. Preoperative administration of DEX compared to its immediate postoperative administration showed a similar analgesic effect.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dolor Postoperatorio / Trometamina / Antiinflamatorios no Esteroideos / Cetoprofeno / Analgésicos Tipo de estudio: Clinical_trials / Guideline / Systematic_reviews Límite: Humans Idioma: En Revista: Drug Dev Res Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dolor Postoperatorio / Trometamina / Antiinflamatorios no Esteroideos / Cetoprofeno / Analgésicos Tipo de estudio: Clinical_trials / Guideline / Systematic_reviews Límite: Humans Idioma: En Revista: Drug Dev Res Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos