Recombinant Human Erythropoietin Protects Against Hippocampal Damage in Developing Rats with Seizures by Modulating Autophagy via the S6 Protein in a Time-Dependent Manner.

Li, Qinrui; Han, Ying; Du, Junbao; Jin, Hongfang; Zhang, Jing; Niu, Manman; Qin, Jiong

Li, Qinrui; Han, Ying; Du, Junbao; Jin, Hongfang; Zhang, Jing; Niu, Manman; Qin, Jiong.

Afiliación

Li Q; Department of Pediatrics, Peking University First Hospital, No. 1, Xi-An Men Street, Beijing, 100034, People's Republic of China.
Han Y; Department of Pediatrics, Peking University First Hospital, No. 1, Xi-An Men Street, Beijing, 100034, People's Republic of China. hanying1568@126.com.
Du J; Department of Pediatrics, Peking University First Hospital, No. 1, Xi-An Men Street, Beijing, 100034, People's Republic of China.
Jin H; Department of Pediatrics, Peking University First Hospital, No. 1, Xi-An Men Street, Beijing, 100034, People's Republic of China.
Zhang J; Department of Pediatrics, Peking University First Hospital, No. 1, Xi-An Men Street, Beijing, 100034, People's Republic of China.
Niu M; Department of Pediatrics, Peking University First Hospital, No. 1, Xi-An Men Street, Beijing, 100034, People's Republic of China.
Qin J; Department of Pediatrics, Peking University People's Hospital, No. 11, Xi Zhi Men Street, Beijing, 100044, People's Republic of China. qinjiong@pkuph.edu.cn.

Neurochem Res ; 43(2): 465-476, 2018 Feb.

Article en En | MEDLINE | ID: mdl-29238892

Asunto(s)

Autofagia/efectos de los fármacos; Eritropoyetina/farmacología; Hipocampo/efectos de los fármacos; Neuronas/efectos de los fármacos; Animales; Lesiones Encefálicas/tratamiento farmacológico; Lesiones Encefálicas/metabolismo; Epilepsia/tratamiento farmacológico; Epilepsia/metabolismo; Hipocampo/metabolismo; Humanos; Masculino; Neuronas/metabolismo; Fármacos Neuroprotectores/farmacología; Ratas Sprague-Dawley; Proteínas Recombinantes/metabolismo; Proteínas Quinasas S6 Ribosómicas/metabolismo; Convulsiones/tratamiento farmacológico; Convulsiones/metabolismo; Factores de Tiempo

Palabras clave

Autophagy; Kainic acid; Mammalian target of rapamycin complex 1 (mTORC1) pathway; Recombinant human erythropoietin (rhEPO); Seizure

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Autofagia / Eritropoyetina / Hipocampo / Neuronas Límite: Animals / Humans / Male Idioma: En Revista: Neurochem Res Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos

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