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Development of solid dispersions of ß-lapachone in PEG and PVP by solvent evaporation method.
Dos Santos, Klecia M; Barbosa, Raquel de Melo; Vargas, Fernanda Grace A; de Azevedo, Eduardo Pereira; Lins, Antônio Cláudio da Silva; Camara, Celso A; Aragão, Cícero F S; Moura, Tulio Flavio de Lima E; Raffin, Fernanda Nervo.
Afiliación
  • Dos Santos KM; a Department of Pharmacy , University of Rio Grande do Norte , Natal , Rio Grande do Norte , Brazil.
  • Barbosa RM; a Department of Pharmacy , University of Rio Grande do Norte , Natal , Rio Grande do Norte , Brazil.
  • Vargas FGA; a Department of Pharmacy , University of Rio Grande do Norte , Natal , Rio Grande do Norte , Brazil.
  • de Azevedo EP; b Graduate Program in Biotechnology , Laureate International Universities, Universidade Potiguar - UnP , Natal , Rio Grande do Norte , Brazil.
  • Lins ACDS; c Department of Chemistry , Federal Rural University of Pernambuco , Recife , Pernambuco , Brazil.
  • Camara CA; c Department of Chemistry , Federal Rural University of Pernambuco , Recife , Pernambuco , Brazil.
  • Aragão CFS; a Department of Pharmacy , University of Rio Grande do Norte , Natal , Rio Grande do Norte , Brazil.
  • Moura TFLE; a Department of Pharmacy , University of Rio Grande do Norte , Natal , Rio Grande do Norte , Brazil.
  • Raffin FN; a Department of Pharmacy , University of Rio Grande do Norte , Natal , Rio Grande do Norte , Brazil.
Drug Dev Ind Pharm ; 44(5): 750-756, 2018 May.
Article en En | MEDLINE | ID: mdl-29206496
ß-lapachone (ßlap) has shown potential use in various medical applications. However, its poor solubility has limited its systemic administration and clinical applications. The aim of this work is to develop solid dispersions of ßlap using poly (ethylene glycol) (PEG 6000) and polyvinylpyrrolidone (PVP K30) as hydrophilic polymers and evaluate the dissolution rate in aqueous medium. Solid dispersions were prepared by solvent evaporation method using different weight ratios of ßlap and hydrophilic polymer (1:1, 1:2, and 1:3). Characterization performed by differential scanning calorimetry, Fourier transform infrared spectroscopy, X-ray diffraction, and scanning electron microscopy showed that ßlap was molecularly dispersed within the polymer matrix. The in vitro dissolution tests showed an enhancement in the dissolution profile of ßlap as solid dispersions prepared in both PVP and PEG, although the former showed better results. The drug:polymer ratio influenced ßlap dissolution rate, as higher amounts of hydrophilic polymer led to enhanced drug dissolution. Thus, this study demonstrated that solid dispersions of ßlap in PVP offers an effective way to overcome the poor dissolution of ßlap.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polietilenglicoles / Polímeros / Naftoquinonas / Povidona Idioma: En Revista: Drug Dev Ind Pharm Año: 2018 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polietilenglicoles / Polímeros / Naftoquinonas / Povidona Idioma: En Revista: Drug Dev Ind Pharm Año: 2018 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido