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microRNA Expression in Ethnic Specific Early Stage Breast Cancer: an Integration and Comparative Analysis.
Nassar, Farah J; Talhouk, Rabih; Zgheib, Nathalie K; Tfayli, Arafat; El Sabban, Maya; El Saghir, Nagi S; Boulos, Fouad; Jabbour, Mark N; Chalala, Claude; Boustany, Rose-Mary; Kadara, Humam; Zhang, Zhou; Zheng, Yinan; Joyce, Brian; Hou, Lifang; Bazarbachi, Ali; Calin, George; Nasr, Rihab.
Afiliación
  • Nassar FJ; Department of Biology, Faculty of Arts and Sciences, American University of Beirut, Beirut, Lebanon.
  • Talhouk R; Department of Biology, Faculty of Arts and Sciences, American University of Beirut, Beirut, Lebanon.
  • Zgheib NK; Department of Pharmacology and Toxicology, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
  • Tfayli A; Department of Internal Medicine, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
  • El Sabban M; Department of Biochemistry, Medical University of South Carolina, Charleston, South Carolina, USA.
  • El Saghir NS; Department of Internal Medicine, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
  • Boulos F; Department of Pathology, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
  • Jabbour MN; Department of Pathology, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
  • Chalala C; Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK.
  • Boustany RM; Department of Pediatrics and Adolescent Medicine, American University of Beirut Medical Center, Beirut, Lebanon.
  • Kadara H; Department of Biochemistry and Molecular Genetics, American University of Beirut Medical Center, Beirut, Lebanon.
  • Zhang Z; Duke University Medical Center, Durham, NC, USA.
  • Zheng Y; Department of Biochemistry and Molecular Genetics, American University of Beirut Medical Center, Beirut, Lebanon.
  • Joyce B; Center for Population Epigenetics, Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
  • Hou L; Driskill Graduate Program in Life Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
  • Bazarbachi A; Center for Population Epigenetics, Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
  • Calin G; Institute for Public Health and Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
  • Nasr R; Center for Population Epigenetics, Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Sci Rep ; 7(1): 16829, 2017 12 04.
Article en En | MEDLINE | ID: mdl-29203780
Breast cancer (BC) has a higher incidence in young Lebanese woman as compared to the West. We assessed the microRNA (miRNA) microarray profile of tissues derived from Lebanese patients with early BC and performed mRNA-miRNA integration analysis. 173 miRNAs were significantly dysregulated in 45 BC versus 17 normal adjacent breast tissues, including 74 with a fold change more than two of which 17 were never reported before in cancer. Integration analysis of mRNA-miRNA microarray data revealed a potential role of 51 dysregulated miRNA regulating 719 tumor suppressive or oncogenic mRNA associated with increased proliferation and decreased migration and invasion. We then performed a comparative miRNA microarray profile analysis of BC tissue between these 45 Lebanese and 197 matched American BC patients. Notably, Lebanese BC patients had 21 exclusively dysregulated miRNA (e.g. miR-31, 362-3p, and 663) and 4 miRNA with different expression manner compared to American patients (e.g. miR-1288-star and 324-3p). Some of these differences could reflect variation in patient age at diagnosis or ethnic variation affecting miRNA epigenetic regulation or sequence of miRNA precursors. Our data provide a basis for genetic/epigenetic investigations to explore the role of miRNA in early stage BC in young women, including ethnic specific differences.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / MicroARNs Límite: Adult / Female / Humans País/Región como asunto: America do norte / Asia Idioma: En Revista: Sci Rep Año: 2017 Tipo del documento: Article País de afiliación: Líbano Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / MicroARNs Límite: Adult / Female / Humans País/Región como asunto: America do norte / Asia Idioma: En Revista: Sci Rep Año: 2017 Tipo del documento: Article País de afiliación: Líbano Pais de publicación: Reino Unido