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Effects of supervised exercise training on lower-limb cutaneous microvascular reactivity in adults with venous ulcers.
Tew, Garry A; Gumber, Anil; McIntosh, Emma; Kesterton, Sue; King, Brenda; Michaels, Jonathan A; Klonizakis, Markos.
Afiliación
  • Tew GA; Department of Sport, Exercise and Rehabilitation, Northumbria University, Newcastle-upon-Tyne, NE1 8ST, UK.
  • Gumber A; Centre for Health and Social Care Research, Sheffield Hallam University, Sheffield, S10 2BP, UK.
  • McIntosh E; Centre for Sport and Exercise Science, Sheffield Hallam University, Sheffield, S10 2BP, UK.
  • Kesterton S; Centre for Sport and Exercise Science, Sheffield Hallam University, Sheffield, S10 2BP, UK.
  • King B; Manor Clinic, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, S12 2ST, UK.
  • Michaels JA; School of Health and Related Research, University of Sheffield, Sheffield, S1 4DA, UK.
  • Klonizakis M; Centre for Sport and Exercise Science, Sheffield Hallam University, Sheffield, S10 2BP, UK. M.Klonizakis@shu.ac.uk.
Eur J Appl Physiol ; 118(2): 321-329, 2018 Feb.
Article en En | MEDLINE | ID: mdl-29197931
PURPOSE: To investigate the effects of a 12-week supervised exercise programme on lower-limb cutaneous microvascular reactivity in adults with venous leg ulceration. METHODS: Thirty-eight adults with unilateral venous ulceration who were being treated with lower-limb compression therapy (58% male; mean age 65 years; median ulcer size 5 cm2) were randomly allocated to exercise or control groups. Exercise participants (n = 18) were invited to attend thrice weekly sessions of lower-limb aerobic and resistance exercise for 12 weeks. Cutaneous microvascular reactivity was assessed in the gaiter region of ulcerated and non-ulcerated legs at baseline and 3 months using laser Doppler fluxmetry coupled with iontophoresis of acetylcholine (ACh) and sodium nitroprusside (SNP). Cutaneous vascular conductance (CVC) was calculated as laser Doppler flux (AU)/mean arterial pressure (mmHg). RESULTS: Thirty-seven participants completed follow-up assessments. Median session attendance was 36 (range 2-36). Analyses of covariance revealed greater peak CVC responses to ACh in the exercise group at 3 months in both the ulcerated (adjusted difference = 0.944 AU/mmHg; 95% CI 0.504-1.384) and non-ulcerated (adjusted difference = 0.596 AU/mmHg; 95% CI 0.028-1.164) legs. Peak CVC responses to SNP were also greater in the exercise group at 3 months in the ulcerated leg (adjusted difference = 0.882 AU/mmHg; 95% CI 0.274-1.491), but not the non-ulcerated leg (adjusted difference = 0.392 AU/mmHg; 95% CI - 0.377 to 1.161). CONCLUSION: Supervised exercise training improves lower-limb cutaneous microvascular reactivity in adults with venous leg ulceration.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Úlcera Varicosa / Extremidad Inferior / Terapia por Ejercicio / Microvasos Tipo de estudio: Clinical_trials Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Eur J Appl Physiol Asunto de la revista: FISIOLOGIA Año: 2018 Tipo del documento: Article Pais de publicación: Alemania
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Úlcera Varicosa / Extremidad Inferior / Terapia por Ejercicio / Microvasos Tipo de estudio: Clinical_trials Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Eur J Appl Physiol Asunto de la revista: FISIOLOGIA Año: 2018 Tipo del documento: Article Pais de publicación: Alemania