Synthesis and antitumor activity of novel 2, 3-didithiocarbamate substituted naphthoquinones as inhibitors of pyruvate kinase M2 isoform.

Ning, Xianling; Qi, Hailong; Li, Ridong; Jin, Yan; McNutt, Michael A; Yin, Yuxin

Ning, Xianling; Qi, Hailong; Li, Ridong; Jin, Yan; McNutt, Michael A; Yin, Yuxin.

Afiliación

Ning X; a Institute of Systems Biomedicine, School of Basic Medical Sciences , Beijing Key Laboratory of Tumor Systems Biology, Peking University Health Science Center , Beijing , China.
Qi H; b Department of Pharmacology, School of Basic Medical Sciences , Peking University Health Science Center , Beijing , China.
Li R; a Institute of Systems Biomedicine, School of Basic Medical Sciences , Beijing Key Laboratory of Tumor Systems Biology, Peking University Health Science Center , Beijing , China.
Jin Y; c Peking-Tsinghua Center for Life Sciences, Peking University Health Science Center , Beijing , China.
McNutt MA; a Institute of Systems Biomedicine, School of Basic Medical Sciences , Beijing Key Laboratory of Tumor Systems Biology, Peking University Health Science Center , Beijing , China.
Yin Y; b Department of Pharmacology, School of Basic Medical Sciences , Peking University Health Science Center , Beijing , China.

J Enzyme Inhib Med Chem ; 33(1): 126-129, 2018 Dec.

Article en En | MEDLINE | ID: mdl-29185365

Asunto(s)

Antineoplásicos/farmacología; Inhibidores Enzimáticos/farmacología; Naftoquinonas/farmacología; Piruvato Quinasa/antagonistas & inhibidores; Antineoplásicos/síntesis química; Antineoplásicos/química; Proliferación Celular/efectos de los fármacos; Relación Dosis-Respuesta a Droga; Ensayos de Selección de Medicamentos Antitumorales; Inhibidores Enzimáticos/síntesis química; Inhibidores Enzimáticos/química; Humanos; Estructura Molecular; Naftoquinonas/síntesis química; Naftoquinonas/química; Piruvato Quinasa/metabolismo; Relación Estructura-Actividad; Células Tumorales Cultivadas

Palabras clave

2,3-didithiocarbamate substituted naphthoquinones; M2 isoform of pyruvate kinase; PKM2 inhibitors; antiproliferative effects

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piruvato Quinasa / Naftoquinonas / Inhibidores Enzimáticos / Antineoplásicos Límite: Humans Idioma: En Revista: J Enzyme Inhib Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2018 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido

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