Crystallographic resolution and crystal and molecular structures of stereoisomers of 1,3,5-triglycidyl-s-triazinetrione.

Hempel, A; Camerman, N; Camerman, A

Hempel, A; Camerman, N; Camerman, A.

Afiliación

Hempel A; Biochemistry Department, University of Toronto, Ontario, Canada.

J Med Chem ; 32(3): 648-51, 1989 Mar.

Article en En | MEDLINE | ID: mdl-2918513

RESUMEN

The crystal and molecular structures of alpha and beta isomers of the antineoplastic alkylating agent 1,3,5-triglycidyl-s-triazinetrione (TGT) have been determined by X-ray diffraction. Although the isomers differ chemically only in the order of a carbon and an oxygen atom in one of the glycidyl epoxide rings, the molecular conformations and crystal packing arrangements are very different. The different physical and biological properties of the two stereoisomers can be explained on the basis of the structures. The sample of alpha-TGT was found to be a mixture of alpha and beta forms, and it is suggested that use of pure alpha-TGT may lead to better therapeutic results.

Asunto(s)

Triazinas; Fenómenos Químicos; Química; Cristalografía; Modelos Moleculares; Conformación Molecular; Estructura Molecular; Estereoisomerismo

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Triazinas Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 1989 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos

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