Lack of specificity of polyunsaturated fats in the inhibition of rat liver glucose-6-phosphate dehydrogenase.
J Nutr
; 119(2): 161-5, 1989 Feb.
Article
en En
| MEDLINE
| ID: mdl-2918386
The mechanism of the effect of polyunsaturated fatty acids (PUFA) on glucose-6-phosphate dehydrogenase (EC 1.1.1.49) (G6PDH) was studied in young, male Wistar rats. Starvation-refeeding increased G6PDH level above that seen in ad libitum-fed animals (enzyme overshoot). A second episode of starvation-refeeding produced even higher levels of G6PDH activity (induction increment). Interposing a high fat diet (containing PUFA) between starvation and feeding the inducer diet abolished one-half to two-thirds of the overshoot. Feeding a high fat diet between the two starvations abolished the induction increment. Inhibitors of arachidonic acid metabolism were not able to reverse the PUFA effect. In another set of experiments it was shown that both linoleic and linolenic acid are equally effective in either reducing the overshoot or abolishing the induction increment. The evidence was interpreted as supporting a hypothesis that the PUFA effect does not require the formation of a specific end product of arachidonic metabolism in a direct way.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Grasas Insaturadas en la Dieta
/
Ácidos Grasos Insaturados
/
Glucosafosfato Deshidrogenasa
/
Hígado
Límite:
Animals
Idioma:
En
Revista:
J Nutr
Año:
1989
Tipo del documento:
Article
Pais de publicación:
Estados Unidos