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Outcome of children and adolescents with relapsed Hodgkin lymphoma treated with high-dose therapy and autologous stem cell transplantation: the Memorial Sloan Kettering Cancer Center experience.
Giulino-Roth, Lisa; O'Donohue, Tara; Chen, Zhengming; Trippett, Tanya M; Klein, Elizabeth; Kernan, Nancy A; Kobos, Rachel; Prockop, Susan E; Scaradavou, Andromachi; Shukla, Neerav; Steinherz, Peter G; Moskowitz, Alison J; Moskowitz, Craig H; Boulad, Farid.
Afiliación
  • Giulino-Roth L; a Department of Pediatrics , Weill Cornell Medical College , New York , NY , USA.
  • O'Donohue T; b Department of Pediatrics , Memorial Sloan Kettering Cancer Center , New York , NY , USA.
  • Chen Z; a Department of Pediatrics , Weill Cornell Medical College , New York , NY , USA.
  • Trippett TM; b Department of Pediatrics , Memorial Sloan Kettering Cancer Center , New York , NY , USA.
  • Klein E; c Division of Biostatistics and Epidemiology, Department of Healthcare Policy and Research , Weill Cornell Medical College , New York , NY , USA.
  • Kernan NA; b Department of Pediatrics , Memorial Sloan Kettering Cancer Center , New York , NY , USA.
  • Kobos R; b Department of Pediatrics , Memorial Sloan Kettering Cancer Center , New York , NY , USA.
  • Prockop SE; b Department of Pediatrics , Memorial Sloan Kettering Cancer Center , New York , NY , USA.
  • Scaradavou A; b Department of Pediatrics , Memorial Sloan Kettering Cancer Center , New York , NY , USA.
  • Shukla N; b Department of Pediatrics , Memorial Sloan Kettering Cancer Center , New York , NY , USA.
  • Steinherz PG; b Department of Pediatrics , Memorial Sloan Kettering Cancer Center , New York , NY , USA.
  • Moskowitz AJ; b Department of Pediatrics , Memorial Sloan Kettering Cancer Center , New York , NY , USA.
  • Moskowitz CH; b Department of Pediatrics , Memorial Sloan Kettering Cancer Center , New York , NY , USA.
  • Boulad F; d Department of Medicine , Memorial Sloan Kettering Cancer Center , New York , NY , USA.
Leuk Lymphoma ; 59(8): 1861-1870, 2018 08.
Article en En | MEDLINE | ID: mdl-29183202
To evaluate outcomes and prognostic markers among children with relapsed Hodgkin lymphoma (HL) treated with autologous stem cell transplant (ASCT), we conducted a retrospective analysis of 36 consecutive pediatric patients treated at Memorial Sloan Kettering Cancer Center from 1989 to 2013. With a median follow-up of 9.6 years, the 10-year overall survival (OS) and event-free survival (EFS) were 74.1 and 67.1% respectively. Absence of B-symptoms, chemotherapy-sensitive disease, and transplant date after 1997 were each associated with superior EFS [HR 0.12 (p = .0015), 0.18 (p = .0039), and 0.17 (p = .0208), respectively]. Childhood Hodgkin International Prognostic Score at relapse (R-CHIPS) was calculated in a subset of patients (n = 22) and a lower score was associated with improved OS (HR 0.29, p = .0352) and a trend toward improved EFS (HR 0.38, p = .0527). In summary, ASCT results in durable remission for the majority of pediatric patients with relapsed HL. R-CHIPS should be evaluated in larger cohorts as a potential predictive tool.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Hodgkin / Protocolos de Quimioterapia Combinada Antineoplásica / Trasplante de Células Madre Hematopoyéticas Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Child / Female / Humans / Male Idioma: En Revista: Leuk Lymphoma Asunto de la revista: HEMATOLOGIA / NEOPLASIAS Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Hodgkin / Protocolos de Quimioterapia Combinada Antineoplásica / Trasplante de Células Madre Hematopoyéticas Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Child / Female / Humans / Male Idioma: En Revista: Leuk Lymphoma Asunto de la revista: HEMATOLOGIA / NEOPLASIAS Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos