[The value of alpha-methylacyl-CoA racemase expression in the progression of colonic carcinoma]. / Valor de la expresión inmunohistoquímica de alfa-metilacil-CoA racemasa en la progresión del carcinoma de colon.
Rev Esp Patol
; 50(1): 15-21, 2017.
Article
en Es
| MEDLINE
| ID: mdl-29179959
Alpha-methylacyl-CoA racemase (AMACR) expression has been demonstrated in several normal tissues and in diverse types of carcinoma. Our aim was to analyze the immunohistochemical expression of AMACR in the sequence-progression of colonic cancer. We studied 237 cases, including samples of normal mucosa of the colon, adenomas with different degrees of dysplasia, colonic carcinomas, lymph nodes and liver metastases of colonic carcinomas. A scale of intensity and percentage of expression was used to analyze the AMACR immunohistochemical profile. The expression was nearly absent in samples of normal mucosa, increased in both adenomas and carcinomas, decreased in lymph node metastases but was significantly increased in liver metastases.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Adenocarcinoma
/
Racemasas y Epimerasas
/
Proteínas de Neoplasias
Límite:
Aged
/
Aged80
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Female
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Humans
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Male
/
Middle aged
Idioma:
Es
Revista:
Rev Esp Patol
Año:
2017
Tipo del documento:
Article
Pais de publicación:
España