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Immunochemotherapy mediated by thermosponge nanoparticles for synergistic anti-tumor effects.
Zhao, Yongdan; Song, Qingle; Yin, Yijia; Wu, Tingting; Hu, Xiaomeng; Gao, Xueqin; Li, Gao; Tan, Songwei; Zhang, Zhiping.
Afiliación
  • Zhao Y; Tongji School of Pharmacy, China; Shanxi Medical University, China.
  • Song Q; Tongji School of Pharmacy, China.
  • Yin Y; Tongji School of Pharmacy, China.
  • Wu T; Tongji School of Pharmacy, China.
  • Hu X; Tongji School of Pharmacy, China.
  • Gao X; Tongji School of Pharmacy, China.
  • Li G; Tongji School of Pharmacy, China.
  • Tan S; Tongji School of Pharmacy, China.
  • Zhang Z; Tongji School of Pharmacy, China; National Engineering Research Center for Nanomedicine, China; Hubei Engineering Research Center for Novel Drug Delivery System, Huazhong University of Science and Technology, Wuhan 430030, China. Electronic address: zhipingzhang@mail.hust.edu.cn.
J Control Release ; 269: 322-336, 2018 01 10.
Article en En | MEDLINE | ID: mdl-29174440
The efficacy of immunotherapy was demonstrated to be compromised by reduced immunogenicity of tumor cells and enhanced suppressive properties of the tumor microenvironment in cancer treatment. There is growing evidence that low-dose chemotherapy can modulate the immune system to improve the anti-tumor effects of immunotherapy through multiple mechanisms, including the enhancement of tumor immunogenicity and reversal of the immunosuppressive tumor microenvironment. Here, we fabricated thermosponge nanoparticles (TSNs) for the co-delivery of chemotherapeutic drug paclitaxel (PTX) and immunostimulant interleukin-2 (IL-2) to explore the synergistic anti-tumor effects of chemotherapy and immunotherapy. The distinct temperature-responsive swelling/deswelling character facilitated the effective post-entrapment of cytokine IL-2 in nanoparticles by a facile non-solvent mild incubation method with unaffected bioactivity and favorable pharmacokinetics. PTX and IL-2 co-loaded TSNs exhibited significant inhibition on tumor growth and metastasis, and prolonged overall survival for tumor-bearing mice compared with the corresponding monotherapies. The synergistic effect was evidenced from the remodeled tumor microenvironment in which low-dose chemotherapeutics disrupted the immunosuppressive tumor microenvironment and enhanced tumor immunogenicity, and immunostimulant cytokine promoted the anti-tumor immune response of immune effector cells. The immunochemotherapy mediated by this thermosponge nanoplatform may provide a promising treatment strategy against cancer.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Interleucina-2 / Paclitaxel / Nanopartículas / Inmunoterapia / Antineoplásicos / Antineoplásicos Fitogénicos Límite: Animals Idioma: En Revista: J Control Release Asunto de la revista: FARMACOLOGIA Año: 2018 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Interleucina-2 / Paclitaxel / Nanopartículas / Inmunoterapia / Antineoplásicos / Antineoplásicos Fitogénicos Límite: Animals Idioma: En Revista: J Control Release Asunto de la revista: FARMACOLOGIA Año: 2018 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos