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Characterization of multiple life stages of two Australian Fasciola hepatica isolates in sheep.
George, S D; Baker, K; Lake, L; Vanhoff, K; D'Arcy, R; Emery, D; Rolfe, P F.
Afiliación
  • George SD; Faculty of Veterinary Science, University of Sydney, 425 Werombi Road, Camden, NSW 2570, Australia; Elanco Australasia Pty Limited, Yarrandoo R&D Centre, 245 Western Road, Kemps Creek, NSW 2178, Australia. Electronic address: sarah.george@elanco.com.
  • Baker K; Elanco Australasia Pty Limited, Yarrandoo R&D Centre, 245 Western Road, Kemps Creek, NSW 2178, Australia.
  • Lake L; Elanco Australasia Pty Limited, Yarrandoo R&D Centre, 245 Western Road, Kemps Creek, NSW 2178, Australia.
  • Vanhoff K; Elanco Australasia Pty Limited, Yarrandoo R&D Centre, 245 Western Road, Kemps Creek, NSW 2178, Australia.
  • D'Arcy R; Elanco Australasia Pty Limited, Yarrandoo R&D Centre, 245 Western Road, Kemps Creek, NSW 2178, Australia.
  • Emery D; Faculty of Veterinary Science, University of Sydney, 425 Werombi Road, Camden, NSW 2570, Australia.
  • Rolfe PF; Elanco Australasia Pty Limited, Yarrandoo R&D Centre, 245 Western Road, Kemps Creek, NSW 2178, Australia.
Vet Parasitol ; 248: 4-9, 2017 Dec 15.
Article en En | MEDLINE | ID: mdl-29173540
Information on the susceptibility status of Fasciola hepatica isolates is lacking in the literature, even for those isolates considered to be laboratory reference strains. Four controlled efficacy studies were conducted on two Fasciola hepatica isolates from Australia, viz. 'Oberon' and 'Sunny Corner' with treatment at either 2, 6 or 10 weeks post-infection (wpi) as defined in each study. Fluke burdens and examination of livers occurred at necropsy in weeks 12 (Study 1) or 13 (Studies 2, 3 and 4) post-infection. The triclabendazole (TCBZ) resistance status of the Oberon isolate was confirmed in 6 and 10-week old F. hepatica, utilizing the drug alone (Fasinex; 71.5% and 31.1%, respectively) and in combination with oxfendazole (Flukazole C; 79.9% and 0%, respectively). The susceptibility of this isolate to albendazole, as well as salicylanilide and sulphonamide drugs was confirmed. The Sunny Corner isolate was confirmed as susceptible to TCBZ (>99% all stages) and closantel (>90% at ≥6 wpi).
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades de las Ovejas / Resistencia a Medicamentos / Fasciola hepatica / Fascioliasis / Antiplatelmínticos Límite: Animals País/Región como asunto: Oceania Idioma: En Revista: Vet Parasitol Año: 2017 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades de las Ovejas / Resistencia a Medicamentos / Fasciola hepatica / Fascioliasis / Antiplatelmínticos Límite: Animals País/Región como asunto: Oceania Idioma: En Revista: Vet Parasitol Año: 2017 Tipo del documento: Article Pais de publicación: Países Bajos