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Brain substrates of early (4h) cigarette abstinence: Identification of treatment targets.
Franklin, Teresa R; Jagannathan, Kanchana; Hager, Nathan; Fang, Zhuo; Xu, Sihua; Wong, Joyce; Childress, Anna Rose; Detre, John A; Rao, Hengyi; Wetherill, Reagan.
Afiliación
  • Franklin TR; Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, 19104, USA. Electronic address: teresafr@pennmedicine.upenn.edu.
  • Jagannathan K; Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, 19104, USA.
  • Hager N; Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, 19104, USA.
  • Fang Z; Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, 19104, USA; Department of Neurology, University of Pennsylvania, Philadelphia, PA, 19104, USA; Laboratory of Applied Brain and Cognitive Sciences, Shanghai International Studies University, Shanghai, China.
  • Xu S; Department of Neurology, University of Pennsylvania, Philadelphia, PA, 19104, USA; Laboratory of Applied Brain and Cognitive Sciences, Shanghai International Studies University, Shanghai, China.
  • Wong J; Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, 19104, USA.
  • Childress AR; Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, 19104, USA.
  • Detre JA; Department of Neurology, University of Pennsylvania, Philadelphia, PA, 19104, USA.
  • Rao H; Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, 19104, USA; Department of Neurology, University of Pennsylvania, Philadelphia, PA, 19104, USA; Laboratory of Applied Brain and Cognitive Sciences, Shanghai International Studies University, Shanghai, China.
  • Wetherill R; Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Drug Alcohol Depend ; 182: 78-85, 2018 01 01.
Article en En | MEDLINE | ID: mdl-29172122
INTRODUCTION: Research indicates that overnight nicotine abstinence disrupts neural activity in the mesocorticolimbic reward network; however, less is known about the time course of abstinence-induced brain changes. To examine the potential neural effects of early abstinence, we used arterial spin labeling perfusion fMRI, to measure regional cerebral blood flow (rCBF) changes in the resting brain induced by 4h of nicotine abstinence. METHODS: In a repeated measures design, 5min of resting perfusion fMRI data were acquired in awake nicotine-dependent individuals (eyes open) during 'smoking as usual' (SMK) and following 4h of monitored nicotine abstinence (ABS) conditions (N=20). Conditions were compared using a paired t test in SPM8. Craving was assessed prior to each condition. RESULTS: Compared to SMK, ABS significantly increased craving and reduced rCBF in select regions, including the hippocampus and ventral striatum (cluster corr, α=0.01, 943 contiguous voxels). The magnitude of the abstinence-induced change in rCBF correlated with the magnitude of the change in craving across conditions in select regions, including the medial and lateral orbitofrontal cortices and the anterior ventral insula (r values ranging from 0.59-0.74). CONCLUSIONS: Results show that as few as 4h of abstinence can reduce resting rCBF in multiple nodes of the brain's mesocorticolimbic network, disrupting neural processing. Identifying early withdrawal treatment targets has far-reaching implications, which include thwarting relapse proclivities. Results parallel those of the extant human literature and are in agreement with an extensive preclinical literature showing compromised mesolimbic dopaminergic function and impairments in reward function during nicotine withdrawal.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encéfalo / Imagen por Resonancia Magnética / Ansia / Fumar Cigarrillos Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Adult / Female / Humans / Male Idioma: En Revista: Drug Alcohol Depend Año: 2018 Tipo del documento: Article Pais de publicación: Irlanda
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encéfalo / Imagen por Resonancia Magnética / Ansia / Fumar Cigarrillos Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Adult / Female / Humans / Male Idioma: En Revista: Drug Alcohol Depend Año: 2018 Tipo del documento: Article Pais de publicación: Irlanda