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Presenting symptoms and clinical findings in HPV-positive and HPV-negative oropharyngeal cancer patients.
Carpén, Timo; Sjöblom, Anni; Lundberg, Marie; Haglund, Caj; Markkola, Antti; Syrjänen, Stina; Tarkkanen, Jussi; Mäkitie, Antti; Hagström, Jaana; Mattila, Petri.
Afiliación
  • Carpén T; a Department of Otorhinolaryngology - Head and Neck Surgery , University of Helsinki and Helsinki University Hospital , Helsinki , Finland.
  • Sjöblom A; b Department of Pathology , Haartman Institute and HUSLAB, University of Helsinki and Helsinki University Hospital , Helsinki , Finland.
  • Lundberg M; a Department of Otorhinolaryngology - Head and Neck Surgery , University of Helsinki and Helsinki University Hospital , Helsinki , Finland.
  • Haglund C; c Department of Surgery , University of Helsinki and Helsinki University Hospital , Helsinki , Finland.
  • Markkola A; d Department of Radiology , University of Helsinki and Helsinki University Hospital , Helsinki , Finland.
  • Syrjänen S; e Department of Oral Pathology and Oral Radiology , University of Turku and Turku University Hospital , Turku , Finland.
  • Tarkkanen J; b Department of Pathology , Haartman Institute and HUSLAB, University of Helsinki and Helsinki University Hospital , Helsinki , Finland.
  • Mäkitie A; a Department of Otorhinolaryngology - Head and Neck Surgery , University of Helsinki and Helsinki University Hospital , Helsinki , Finland.
  • Hagström J; f Division of Ear, Nose and Throat Diseases, Department of Clinical Sciences , Intervention and Technology, Karolinska Institutet and Karolinska Hospital , Stockholm , Sweden.
  • Mattila P; b Department of Pathology , Haartman Institute and HUSLAB, University of Helsinki and Helsinki University Hospital , Helsinki , Finland.
Acta Otolaryngol ; 138(5): 513-518, 2018 05.
Article en En | MEDLINE | ID: mdl-29161981
OBJECTIVES: Oropharyngeal squamous cell carcinoma (OPSCC) is divided in two different disease entities depending on HPV involvement. We investigated differences in presenting symptoms and clinical findings in patients with HPV-positive and -negative OPSCC tumors. METHODS: Altogether 118 consecutive patients diagnosed with primary OPSCC between 2012 and 2014 at the Helsinki University Hospital were included. HPV-status of the tumors was assessed by PCR detection of HPV DNA and immunostaining with p16-INK4a antibody. RESULTS: Fifty-one (47.7%) of the patients had HPV-positive and 56 (52.3%) HPV-negative tumors. Forty-nine (49/51, 96.1%) of the HPV+ tumors were also p16+ showing high concordance. The most common presenting symptom among HPV+/p16+ patients was a neck mass (53.1%), whereas any sort of pain in the head and neck area was more frequently related to the HPV-/p16- (60.0%) group. HPV+/p16+ tumors had a tendency to locate in the tonsillar complex and more likely had already spread into regional lymph nodes compared with HPV-/p16- tumors. Smoking and heavy alcohol consumption were significantly more common among HPV−/p16− patients but also rather common among HPV+/p16+ patients [corrected]. CONCLUSIONS: This analysis of symptoms and signs confirm that OPSCC can be dichotomized in two distinct disease entities as defined by HPV status.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma de Células Escamosas / Neoplasias Orofaríngeas / Infecciones por Papillomavirus Tipo de estudio: Diagnostic_studies / Observational_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Acta Otolaryngol Año: 2018 Tipo del documento: Article País de afiliación: Finlandia Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma de Células Escamosas / Neoplasias Orofaríngeas / Infecciones por Papillomavirus Tipo de estudio: Diagnostic_studies / Observational_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Acta Otolaryngol Año: 2018 Tipo del documento: Article País de afiliación: Finlandia Pais de publicación: Reino Unido