The Dynamics of the Gut Microbiome in Multiple Sclerosis in Relation to Disease.

Mowry, Ellen M; Glenn, Justin D

Mowry, Ellen M; Glenn, Justin D.

Afiliación

Mowry EM; Department of Neurology, Johns Hopkins School of Medicine, 600 North Wolfe Street, Pathology 627, Baltimore, MD 21287, USA.
Glenn JD; Department of Neurology, Johns Hopkins School of Medicine, 600 North Wolfe Street, Meyer Building, Room 6-138, Baltimore, MD 21287, USA. Electronic address: jglenn7@jhmi.edu.

Neurol Clin ; 36(1): 185-196, 2018 Feb.

Article en En | MEDLINE | ID: mdl-29157399

RESUMEN

Multiple sclerosis (MS) is a neuroinflammatory autoimmune disease of unknown etiology, although genetic components and environmental triggers are thought to collude to commence pathogenesis. Numerous investigations are now demonstrating the role of the gut microbiota in neuroinflammation and how alterations in its content may be associated with MS disease. This article explores the studies using MS rodent models to determine the roles of gut bacteria in neuroinflammatory disease, evaluate the evidence linking gut bacterial dysbiosis and MS, and give insight into potential MS therapies targeting the gut microbiota currently under investigation.

Asunto(s)

Microbioma Gastrointestinal/fisiología; Esclerosis Múltiple/microbiología; Esclerosis Múltiple/fisiopatología; Animales; Humanos; Esclerosis Múltiple/inmunología; Neuroinmunomodulación

Palabras clave

Experimental autoimmune encephalomyelitis; Gut bacteria; Gut microbiome; Multiple sclerosis; Neuroinflammation

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Microbioma Gastrointestinal / Esclerosis Múltiple Límite: Animals / Humans Idioma: En Revista: Neurol Clin Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

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