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Gender differences in pain and patient reported outcomes: a secondary analysis of the NCIC CTG SC. 23 randomized trial.
Chow, Selina; Ding, Keyue; Wan, Bo Angela; Brundage, Michael; Meyer, Ralph M; Nabid, Abdenour; Chabot, Pierre; Coulombe, Genevievev; Ahmed, Shahida; Kuk, Joda; Dar, A Rashid; Mahmud, Aamer; Fairchild, Alysa; Wilson, Carolyn F; Wu, Jackson S Y; Dennis, Kristopher; DeAngelis, Carlo; Wong, Rebecca K S; Zhu, Liting; Chow, Edward.
Afiliación
  • Chow S; Sunnybrook Odette Cancer Centre, University of Toronto, Toronto, ON, Canada.
  • Ding K; Canadian Cancer Trials Group, Cancer Research Institute, Queen's University, Kingston, ON, Canada.
  • Wan BA; Sunnybrook Odette Cancer Centre, University of Toronto, Toronto, ON, Canada.
  • Brundage M; Department of Radiation Oncology, Queen's University, Kingston, ON, Canada.
  • Meyer RM; Juravinski Hospital and Cancer Centre, McMaster University, Hamilton, ON, Canada.
  • Nabid A; Department of Radiation Oncology, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada.
  • Chabot P; Department of Radiation Oncology, Hopital Maisonneuve-Rosemont, Montreal, QC, Canada.
  • Coulombe G; Department of Radiation Oncology, CHUM-Hopital NotreDame, Montreal, QC, Canada.
  • Ahmed S; Cancer Care Manitoba, Winnipeg, MB, Canada.
  • Kuk J; Grand River Regional Cancer Centre, Grand River Hospital, Kitchener, ON, Canada.
  • Dar AR; London Regional Cancer Program, London, ON, Canada.
  • Mahmud A; Cancer Centre of Southeastern Ontario, Kingston General Hospital, Kingston, ON, Canada.
  • Fairchild A; Cross Cancer Institute, Edmonton, AB, Canada.
  • Wilson CF; Canadian Cancer Trials Group, Cancer Research Institute, Queen's University, Kingston, ON, Canada.
  • Wu JSY; Tom Baker Cancer Centre, University of Calgary, Calgary, AB, Canada.
  • Dennis K; Department of Radiation Oncology, the Ottawa Hospital and University of Ottawa, Ottawa, ON, Canada.
  • DeAngelis C; Sunnybrook Odette Cancer Centre, University of Toronto, Toronto, ON, Canada; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada.
  • Wong RKS; Princess Margaret Cancer Centre, Radiation Medicine Program, Ontario Cancer Institute, University of Toronto, Toronto, ON, Canada.
  • Zhu L; Canadian Cancer Trials Group, Cancer Research Institute, Queen's University, Kingston, ON, Canada.
  • Chow E; Sunnybrook Odette Cancer Centre, University of Toronto, Toronto, ON, Canada. edward.chow@sunnybrook.ca.
Ann Palliat Med ; 6(Suppl 2): S185-S194, 2017 Dec.
Article en En | MEDLINE | ID: mdl-29156903
BACKGROUND: Gender differences may contribute to variations in disease presentations and health outcomes. To explore the gender difference in pain and patient reported outcomes in cancer patients with bone metastases undergoing palliative radiotherapy on the National Cancer Institute of Canada (NCIC) SC.23 randomized trial. METHODS: Patients completed the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life (QOL) bone metastases module (QLQ-BM22) and EORTC QOL Core-15-Palliative (QLQ-C15-PAL) before treatment and at days 10 and 42 after a single 8 Gy radiation treatment. Patient demographics, performance status, analgesic consumption, BM22 and C15 were compared between males and females using the 2-sample t-test for continuous variables or the Chi-squared test for categorical variables. Multiple linear regression models were used to check the difference between gender groups adjusting for the baseline demographics and primary disease sites. RESULTS: There were 298 patients (170 male, 128 female) with median age of 69 years. The most common primary cancer sites were lung, prostate and breast. At baseline, there were no differences in BM22 and C15 scores, except a worse nausea and vomiting score (P=0.03) in females on the C15. In patients with moderate baseline worst pain scores (WPS), females reported worse scores in painful sites of BM22. At day 42, there was no significant difference in response to radiotherapy. Among the responders, females reported better improvement in emotional aspect. CONCLUSIONS: In cancer patients with bone metastases undergoing palliative radiotherapy, the majority of symptom presentations, patient reported outcomes, and response to radiation was not significantly different between genders. TRIAL REGISTRATION: NCT01248585.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Óseas / Caracteres Sexuales / Dolor en Cáncer / Medición de Resultados Informados por el Paciente Tipo de estudio: Clinical_trials / Prognostic_studies Aspecto: Determinantes_sociais_saude / Patient_preference Límite: Aged / Female / Humans / Male País/Región como asunto: America do norte Idioma: En Revista: Ann Palliat Med Año: 2017 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: China
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Óseas / Caracteres Sexuales / Dolor en Cáncer / Medición de Resultados Informados por el Paciente Tipo de estudio: Clinical_trials / Prognostic_studies Aspecto: Determinantes_sociais_saude / Patient_preference Límite: Aged / Female / Humans / Male País/Región como asunto: America do norte Idioma: En Revista: Ann Palliat Med Año: 2017 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: China