Your browser doesn't support javascript.
loading
COX-2 expression in ovarian cancer: an updated meta-analysis.
Sun, Haiming; Zhang, Xuelong; Sun, Donglin; Jia, Xueyuan; Xu, Lidan; Qiao, Yuandong; Jin, Yan.
Afiliación
  • Sun H; Laboratory of Medical Genetics, Harbin Medical University, Harbin 150081, China.
  • Zhang X; National Human Genome Research Institute, National Institutes of Health, Baltimore, MD 21224, USA.
  • Sun D; Laboratory of Medical Genetics, Harbin Medical University, Harbin 150081, China.
  • Jia X; Laboratory of Medical Genetics, Harbin Medical University, Harbin 150081, China.
  • Xu L; Laboratory of Medical Genetics, Harbin Medical University, Harbin 150081, China.
  • Qiao Y; Laboratory of Medical Genetics, Harbin Medical University, Harbin 150081, China.
  • Jin Y; Laboratory of Medical Genetics, Harbin Medical University, Harbin 150081, China.
Oncotarget ; 8(50): 88152-88162, 2017 Oct 20.
Article en En | MEDLINE | ID: mdl-29152148
The prognostic role of COX-2 expression in ovarian cancer patients has been studied for years, while results remain controversial. Thus we performed a meta-analysis to evaluate the prognostic impact of COX-2 expression on survival of ovarian cancer patients. The databases PubMed, Embase and CNKI were searched. Summary hazard ratio (HR) and 95% confidence intervals (CIs) were calculated to analyze the correlations between COX-2 expression and overall survival (OS), and disease-free survival (DFS). A total of 1,867 patients from 18 studies were enrolled in the final analysis. The results showed that patients with higher COX-2 expression had a poor OS (HR: 1.48; 95% CI: 1.19-1.85) and DFS (HR: 1.81, 95% CI: 1.28-2.55). Subgroup analysis showed that there had significant associations between COX-2 expression and survival rate in most of the subgroups. Furthermore, there were significant associations between COX-2 expression and several clinical parameters such as FIGO stage, histological type and age. These results showed the patients with higher COX-2 expression had a significantly poorer survival rate, COX-2 expression had the potential to be a prognostic marker of ovarian cancer.
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Systematic_reviews Idioma: En Revista: Oncotarget Año: 2017 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Systematic_reviews Idioma: En Revista: Oncotarget Año: 2017 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos