Your browser doesn't support javascript.
loading
4218T/C polymorphism associations with post-cesarean patient-controlled epidural fentanyl consumption and pain perception.
Xie, W; Zhuang, W; Chen, L; Xie, W; Jiang, C; Liu, N.
Afiliación
  • Xie W; Department of Anesthesiology, Quanzhou First Hospital, Quanzhou, China.
  • Zhuang W; Department of Anesthesiology, Huian Hospital, Quanzhou, China.
  • Chen L; Department of Anesthesiology, Huian Hospital, Quanzhou, China.
  • Xie W; Department of Anesthesiology, Quanzhou First Hospital, Quanzhou, China.
  • Jiang C; Department of Anesthesiology, Quanzhou First Hospital, Quanzhou, China.
  • Liu N; Department of Anesthesiology, Quanzhou First Hospital, Quanzhou, China.
Acta Anaesthesiol Scand ; 62(3): 376-383, 2018 03.
Article en En | MEDLINE | ID: mdl-29148033
BACKGROUND: The utilization of intrathecal opioids is an efficacious component of post-cesarean section pain management. Given that growing evidence indicates that calcitonin gene-related peptide (CGRP) plays a key role in the development of peripheral sensitization and is associated with enhanced pain, we hypothesized that CGRP 4218T/C polymorphism is associated with the variability in fentanyl consumption for post-cesarean analgesia. METHODS: We recruited 548 patients who presented for elective cesarean delivery, and used polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method to analyze CGRP 4218T/C polymorphism. We examined the association of CGRP 4218T/C polymorphism and post-operative fentanyl consumption for analgesia as well as adverse reactions to fentanyl in those patients who received cesarean section surgeries. RESULTS: We found that the CGRP 4218T/C polymorphism has a significant effect on pain perception, analgesic requirement, and nausea and vomiting for the first 24 h after cesarean delivery in patients who received PCEA fentanyl. Individuals with the C/C genotype had more pain, required more PCEA fentanyl, and experienced a lower incidence of nausea and vomiting. CONCLUSION: These results indicated that patients with C/C genotype may have reduced sensitivity to fentanyl analgesia and/or increased pain perception, and were more willing to use PCEA fentanyl to manage their pain.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dolor Postoperatorio / Analgesia Epidural / Péptido Relacionado con Gen de Calcitonina / Fentanilo / Analgesia Obstétrica / Analgesia Controlada por el Paciente / Percepción del Dolor / Analgésicos Opioides Tipo de estudio: Risk_factors_studies Límite: Adult / Female / Humans / Pregnancy Idioma: En Revista: Acta Anaesthesiol Scand Año: 2018 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dolor Postoperatorio / Analgesia Epidural / Péptido Relacionado con Gen de Calcitonina / Fentanilo / Analgesia Obstétrica / Analgesia Controlada por el Paciente / Percepción del Dolor / Analgésicos Opioides Tipo de estudio: Risk_factors_studies Límite: Adult / Female / Humans / Pregnancy Idioma: En Revista: Acta Anaesthesiol Scand Año: 2018 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido