Twenty-eight loci form a continuous linkage map of markers for human chromosome 1.

O'Connell, P; Lathrop, G M; Nakamura, Y; Leppert, M L; Ardinger, R H; Murray, J L; Lalouel, J M; White, R

O'Connell, P; Lathrop, G M; Nakamura, Y; Leppert, M L; Ardinger, R H; Murray, J L; Lalouel, J M; White, R.

Afiliación

O'Connell P; Howard Hughes Medical Institute, University of Utah Medical School, Salt Lake City 84132.

Genomics ; 4(1): 12-20, 1989 Jan.

Article en En | MEDLINE | ID: mdl-2914706

RESUMEN

We have used a combination of 30 serological, protein electromorphic, and DNA markers defining 28 loci to construct a linkage map of chromosome 1. These markers form a continuous linkage group of 320 cM in males and 608 cM in females; female genetic distances were on average twofold higher than those of males across the map. Among the DNA markers are 10 highly polymorphic markers reflecting loci that contain a variable number of tandem repeats, well distributed over the length of the chromosome, that will be highly efficient anchor points for application of this map to studies of human genetic disease.

Asunto(s)

Cromosomas Humanos Par 1; Mapeo Cromosómico; Femenino; Ligamiento Genético; Marcadores Genéticos; Humanos; Masculino; Polimorfismo Genético; Recombinación Genética; Factores Sexuales

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cromosomas Humanos Par 1 Límite: Female / Humans / Male Idioma: En Revista: Genomics Asunto de la revista: GENETICA Año: 1989 Tipo del documento: Article Pais de publicación: Estados Unidos

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