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Design of Novel 3-Pyrimidinylazaindole CDK2/9 Inhibitors with Potent In Vitro and In Vivo Antitumor Efficacy in a Triple-Negative Breast Cancer Model.
Singh, Umed; Chashoo, Gousia; Khan, Sameer U; Mahajan, Priya; Nargotra, Amit; Mahajan, Girish; Singh, Amarinder; Sharma, Anjna; Mintoo, Mubashir J; Guru, Santosh Kumar; Aruri, Hariprasad; Thatikonda, Thanusha; Sahu, Promod; Chibber, Pankaj; Kumar, Vikas; Mir, Sameer A; Bharate, Sonali S; Madishetti, Sreedhar; Nandi, Utpal; Singh, Gurdarshan; Mondhe, Dilip Manikrao; Bhushan, Shashi; Malik, Fayaz; Mignani, Serge; Vishwakarma, Ram A; Singh, Parvinder Pal.
Afiliación
  • Singh U; Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Academy of Scientific and Innovative Research , Canal Road, Jammu, Jammu & Kashmir-180001, India.
  • Chashoo G; Cancer Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Academy of Scientific and Innovative Research , Canal Road, Jammu, Jammu & Kashmir-180001, India.
  • Khan SU; Cancer Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Academy of Scientific and Innovative Research , Canal Road, Jammu, Jammu & Kashmir-180001, India.
  • Mahajan P; Discovery Informatics, CSIR-Indian Institute of Integrative Medicine, Academy of Scientific and Innovative Research , Canal Road, Jammu, Jammu & Kashmir-180001, India.
  • Nargotra A; Discovery Informatics, CSIR-Indian Institute of Integrative Medicine, Academy of Scientific and Innovative Research , Canal Road, Jammu, Jammu & Kashmir-180001, India.
  • Mahajan G; Cancer Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Academy of Scientific and Innovative Research , Canal Road, Jammu, Jammu & Kashmir-180001, India.
  • Singh A; Pharmacokinetic & Pharmacodynamic Division, CSIR-Indian Institute of Integrative Medicine, Academy of Scientific and Innovative Research , Canal Road, Jammu, Jammu & Kashmir-180001, India.
  • Sharma A; Pharmacokinetic & Pharmacodynamic Division, CSIR-Indian Institute of Integrative Medicine, Academy of Scientific and Innovative Research , Canal Road, Jammu, Jammu & Kashmir-180001, India.
  • Mintoo MJ; Cancer Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Academy of Scientific and Innovative Research , Canal Road, Jammu, Jammu & Kashmir-180001, India.
  • Guru SK; Cancer Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Academy of Scientific and Innovative Research , Canal Road, Jammu, Jammu & Kashmir-180001, India.
  • Aruri H; Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Academy of Scientific and Innovative Research , Canal Road, Jammu, Jammu & Kashmir-180001, India.
  • Thatikonda T; Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Academy of Scientific and Innovative Research , Canal Road, Jammu, Jammu & Kashmir-180001, India.
  • Sahu P; Pharmacokinetic & Pharmacodynamic Division, CSIR-Indian Institute of Integrative Medicine, Academy of Scientific and Innovative Research , Canal Road, Jammu, Jammu & Kashmir-180001, India.
  • Chibber P; Pharmacokinetic & Pharmacodynamic Division, CSIR-Indian Institute of Integrative Medicine, Academy of Scientific and Innovative Research , Canal Road, Jammu, Jammu & Kashmir-180001, India.
  • Kumar V; Preformulation Division, CSIR-Indian Institute of Integrative Medicine, Academy of Scientific and Innovative Research , Canal Road, Jammu, Jammu & Kashmir-180001, India.
  • Mir SA; Cancer Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Academy of Scientific and Innovative Research , Canal Road, Jammu, Jammu & Kashmir-180001, India.
  • Bharate SS; Preformulation Division, CSIR-Indian Institute of Integrative Medicine, Academy of Scientific and Innovative Research , Canal Road, Jammu, Jammu & Kashmir-180001, India.
  • Madishetti S; Pharmacokinetic & Pharmacodynamic Division, CSIR-Indian Institute of Integrative Medicine, Academy of Scientific and Innovative Research , Canal Road, Jammu, Jammu & Kashmir-180001, India.
  • Nandi U; Pharmacokinetic & Pharmacodynamic Division, CSIR-Indian Institute of Integrative Medicine, Academy of Scientific and Innovative Research , Canal Road, Jammu, Jammu & Kashmir-180001, India.
  • Singh G; Pharmacokinetic & Pharmacodynamic Division, CSIR-Indian Institute of Integrative Medicine, Academy of Scientific and Innovative Research , Canal Road, Jammu, Jammu & Kashmir-180001, India.
  • Mondhe DM; Cancer Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Academy of Scientific and Innovative Research , Canal Road, Jammu, Jammu & Kashmir-180001, India.
  • Bhushan S; Cancer Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Academy of Scientific and Innovative Research , Canal Road, Jammu, Jammu & Kashmir-180001, India.
  • Malik F; Indian Pharmacopoeia Commission , Sector-23, Raj Nagar, Ghaziabad-201002, India.
  • Mignani S; Cancer Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Academy of Scientific and Innovative Research , Canal Road, Jammu, Jammu & Kashmir-180001, India.
  • Vishwakarma RA; Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Academy of Scientific and Innovative Research , Canal Road, Jammu, Jammu & Kashmir-180001, India.
  • Singh PP; PRES Sorbonne Paris Cité, CNRS UMR 860, Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologique, Université Paris Descartes , 45, rue des Saints Péres, 75006 Paris, France.
J Med Chem ; 60(23): 9470-9489, 2017 12 14.
Article en En | MEDLINE | ID: mdl-29144137
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Quinasa 9 Dependiente de la Ciclina / Inhibidores de Proteínas Quinasas / Quinasa 2 Dependiente de la Ciclina / Neoplasias de la Mama Triple Negativas / Indoles Límite: Animals / Female / Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2017 Tipo del documento: Article País de afiliación: India Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Quinasa 9 Dependiente de la Ciclina / Inhibidores de Proteínas Quinasas / Quinasa 2 Dependiente de la Ciclina / Neoplasias de la Mama Triple Negativas / Indoles Límite: Animals / Female / Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2017 Tipo del documento: Article País de afiliación: India Pais de publicación: Estados Unidos