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Clinicopathological and prognostic value of transforming acidic coiled-coil-containing protein 3 (TACC3) expression in soft tissue sarcomas.
Matsuda, Kotaro; Miyoshi, Hiroaki; Hiraoka, Koji; Yokoyama, Shintaro; Haraguchi, Toshiaki; Hashiguchi, Toshihiro; Hamada, Tetsuya; Shiba, Naoto; Ohshima, Koichi.
Afiliación
  • Matsuda K; Department of Pathology, Kurume University School of Medicine, Kurume, Fukuoka, Japan.
  • Miyoshi H; Department of Orthopedic Surgery, Kurume University School of Medicine, Kurume, Fukuoka, Japan.
  • Hiraoka K; Department of Pathology, Kurume University School of Medicine, Kurume, Fukuoka, Japan.
  • Yokoyama S; Department of Orthopedic Surgery, Kurume University School of Medicine, Kurume, Fukuoka, Japan.
  • Haraguchi T; Department of Surgery, Kurume University School of Medicine, Kurume, Fukuoka, Japan.
  • Hashiguchi T; Department of Orthopedic Surgery, Kurume University School of Medicine, Kurume, Fukuoka, Japan.
  • Hamada T; Department of Surgery, Kurume University School of Medicine, Kurume, Fukuoka, Japan.
  • Shiba N; Department of Orthopedic Surgery, Kurume University School of Medicine, Kurume, Fukuoka, Japan.
  • Ohshima K; Department of Orthopedic Surgery, Kurume University School of Medicine, Kurume, Fukuoka, Japan.
PLoS One ; 12(11): e0188096, 2017.
Article en En | MEDLINE | ID: mdl-29135996
Transforming acidic coiled-coil-containing protein 3 (TACC3), a microtubule regulator, is associated with various cancers. However, the relationship between TACC3 and soft tissue sarcomas (STS) remains unclear. We investigated the expression of TACC3 in 136 STS patient samples using immunohistochemical (IHC) staining, and the statistical associations between TACC3 expression and clinicopathological characteristics were evaluated. Additionally, the expression levels of the tumor suppressor p53 and of the cell proliferation marker Ki-67 were also assessed by IHC. High TACC3 expression was detected in 94/136 of STS cases (69.1%), and significantly correlated with higher grade according to the French Fédération Nationale des Centres de Lutte Contre le Cancer system (P<0.0001), poorer tumor differentiation (P<0.0001), increased mitotic counts (P<0.0001), advanced stage per American Joint Committee on Cancer guidelines (P<0.0001), higher p53 expression (P = 0.0487), higher Ki-67 expression (P<0.0001), and undergoing postoperative therapy (P = 0.0001). Disease-free survival (DFS) and overall survival (OS) of patients with high TACC3 expression were significantly shorter (P<0.0001 and P<0.0001, respectively). On multivariate analyses, high TACC3 expression was an independent negative prognostic factor for both DFS and OS (hazard ratio [HR]: 3.074; P = 0.0235 and HR: 8.521; P = 0.0415, respectively). Our results suggest that TACC3 is an independent prognostic factor and may be a novel therapeutic target for the treatment of STS.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sarcoma / Proteínas Asociadas a Microtúbulos Tipo de estudio: Guideline / Prognostic_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2017 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sarcoma / Proteínas Asociadas a Microtúbulos Tipo de estudio: Guideline / Prognostic_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2017 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos