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Binding to SMN2 pre-mRNA-protein complex elicits specificity for small molecule splicing modifiers.
Sivaramakrishnan, Manaswini; McCarthy, Kathleen D; Campagne, Sébastien; Huber, Sylwia; Meier, Sonja; Augustin, Angélique; Heckel, Tobias; Meistermann, Hélène; Hug, Melanie N; Birrer, Pascale; Moursy, Ahmed; Khawaja, Sarah; Schmucki, Roland; Berntenis, Nikos; Giroud, Nicolas; Golling, Sabrina; Tzouros, Manuel; Banfai, Balazs; Duran-Pacheco, Gonzalo; Lamerz, Jens; Hsiu Liu, Ying; Luebbers, Thomas; Ratni, Hasane; Ebeling, Martin; Cléry, Antoine; Paushkin, Sergey; Krainer, Adrian R; Allain, Frédéric H-T; Metzger, Friedrich.
Afiliación
  • Sivaramakrishnan M; F. Hoffmann-La Roche Ltd., Pharma Research & Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, Basel, 4070, Switzerland.
  • McCarthy KD; Cold Spring Harbor Laboratory, P.O. Box 100, 1 Bungtown Road, Cold Spring Harbor, New York, NY, 11724, USA.
  • Campagne S; F. Hoffmann-La Roche Ltd., Pharma Research & Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, Basel, 4070, Switzerland.
  • Huber S; Department of Biology, ETH Zurich, Hönggerbergring 64, Zürich, 8093, Switzerland.
  • Meier S; F. Hoffmann-La Roche Ltd., Pharma Research & Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, Basel, 4070, Switzerland.
  • Augustin A; F. Hoffmann-La Roche Ltd., Pharma Research & Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, Basel, 4070, Switzerland.
  • Heckel T; Cold Spring Harbor Laboratory, P.O. Box 100, 1 Bungtown Road, Cold Spring Harbor, New York, NY, 11724, USA.
  • Meistermann H; F. Hoffmann-La Roche Ltd., Pharma Research & Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, Basel, 4070, Switzerland.
  • Hug MN; F. Hoffmann-La Roche Ltd., Pharma Research & Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, Basel, 4070, Switzerland.
  • Birrer P; F. Hoffmann-La Roche Ltd., Pharma Research & Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, Basel, 4070, Switzerland.
  • Moursy A; F. Hoffmann-La Roche Ltd., Pharma Research & Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, Basel, 4070, Switzerland.
  • Khawaja S; F. Hoffmann-La Roche Ltd., Pharma Research & Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, Basel, 4070, Switzerland.
  • Schmucki R; Department of Biology, ETH Zurich, Hönggerbergring 64, Zürich, 8093, Switzerland.
  • Berntenis N; Department of Biology, ETH Zurich, Hönggerbergring 64, Zürich, 8093, Switzerland.
  • Giroud N; F. Hoffmann-La Roche Ltd., Pharma Research & Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, Basel, 4070, Switzerland.
  • Golling S; F. Hoffmann-La Roche Ltd., Pharma Research & Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, Basel, 4070, Switzerland.
  • Tzouros M; F. Hoffmann-La Roche Ltd., Pharma Research & Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, Basel, 4070, Switzerland.
  • Banfai B; F. Hoffmann-La Roche Ltd., Pharma Research & Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, Basel, 4070, Switzerland.
  • Duran-Pacheco G; F. Hoffmann-La Roche Ltd., Pharma Research & Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, Basel, 4070, Switzerland.
  • Lamerz J; F. Hoffmann-La Roche Ltd., Pharma Research & Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, Basel, 4070, Switzerland.
  • Hsiu Liu Y; F. Hoffmann-La Roche Ltd., Pharma Research & Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, Basel, 4070, Switzerland.
  • Luebbers T; F. Hoffmann-La Roche Ltd., Pharma Research & Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, Basel, 4070, Switzerland.
  • Ratni H; Cold Spring Harbor Laboratory, P.O. Box 100, 1 Bungtown Road, Cold Spring Harbor, New York, NY, 11724, USA.
  • Ebeling M; F. Hoffmann-La Roche Ltd., Pharma Research & Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, Basel, 4070, Switzerland.
  • Cléry A; F. Hoffmann-La Roche Ltd., Pharma Research & Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, Basel, 4070, Switzerland.
  • Paushkin S; F. Hoffmann-La Roche Ltd., Pharma Research & Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, Basel, 4070, Switzerland. martin.ebeling@roche.com.
  • Krainer AR; Department of Biology, ETH Zurich, Hönggerbergring 64, Zürich, 8093, Switzerland.
  • Allain FH; SMA Foundation, 888 Seventh Avenue, Suite 400 New York, New York, NY, 10019, USA.
  • Metzger F; Cold Spring Harbor Laboratory, P.O. Box 100, 1 Bungtown Road, Cold Spring Harbor, New York, NY, 11724, USA.
Nat Commun ; 8(1): 1476, 2017 11 14.
Article en En | MEDLINE | ID: mdl-29133793
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piperazinas / ARN Mensajero / Atrofia Muscular Espinal / Precursores del ARN / Empalme del ARN / Proteínas de Unión al ARN Límite: Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2017 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piperazinas / ARN Mensajero / Atrofia Muscular Espinal / Precursores del ARN / Empalme del ARN / Proteínas de Unión al ARN Límite: Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2017 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Reino Unido