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Staged development of long-lived T-cell receptor αß TH17 resident memory T-cell population to Candida albicans after skin infection.
Park, Chang Ook; Fu, Xiujun; Jiang, Xiaodong; Pan, Youdong; Teague, Jessica E; Collins, Nicholas; Tian, Tian; O'Malley, John T; Emerson, Ryan O; Kim, Ji Hye; Jung, Yookyung; Watanabe, Rei; Fuhlbrigge, Robert C; Carbone, Francis R; Gebhardt, Thomas; Clark, Rachael A; Lin, Charles P; Kupper, Thomas S.
Afiliación
  • Park CO; Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass; Department of Dermatology and Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea.
  • Fu X; Center for Systems Biology and Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Mass.
  • Jiang X; Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass.
  • Pan Y; Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass.
  • Teague JE; Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass.
  • Collins N; Department of Microbiology and Immunology, University of Melbourne, Parkville, Australia.
  • Tian T; Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass.
  • O'Malley JT; Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass.
  • Emerson RO; Adaptive Biotechnologies, Seattle, Wash.
  • Kim JH; Department of Dermatology and Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea.
  • Jung Y; Center for Systems Biology and Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Mass.
  • Watanabe R; Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass.
  • Fuhlbrigge RC; Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass.
  • Carbone FR; Department of Microbiology and Immunology, University of Melbourne, Parkville, Australia.
  • Gebhardt T; Department of Microbiology and Immunology, University of Melbourne, Parkville, Australia.
  • Clark RA; Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass.
  • Lin CP; Center for Systems Biology and Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Mass.
  • Kupper TS; Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass. Electronic address: tkupper@bwh.harvard.edu.
J Allergy Clin Immunol ; 142(2): 647-662, 2018 08.
Article en En | MEDLINE | ID: mdl-29128674
BACKGROUND: Candida albicans is a dimorphic fungus to which human subjects are exposed early in life, and by adulthood, it is part of the mycobiome of skin and other tissues. Neonatal skin lacks resident memory T (TRM) cells, but in adults the C albicans skin test is a surrogate for immunocompetence. Young adult mice raised under specific pathogen-free conditions are naive to C albicans and have been shown recently to have an immune system resembling that of neonatal human subjects. OBJECTIVE: We studied the evolution of the adaptive cutaneous immune response to Candida species. METHODS: We examined both human skin T cells and the de novo and memory immune responses in a mouse model of C albicans skin infection. RESULTS: In mice the initial IL-17-producing cells after C albicans infection were dermal γδ T cells, but by day 7, αß TH17 effector T cells were predominant. By day 30, the majority of C albicans-reactive IL-17-producing T cells were CD4 TRM cells. Intravital microscopy showed that CD4 effector T cells were recruited to the site of primary infection and were highly motile 10 days after infection. Between 30 and 90 days after infection, these CD4 T cells became increasingly sessile, acquired expression of CD69 and CD103, and localized to the papillary dermis. These established TRM cells produced IL-17 on challenge, whereas motile migratory memory T cells did not. TRM cells rapidly clear an infectious challenge with C albicans more effectively than recirculating T cells, although both populations participate. We found that in normal human skin IL-17-producing CD4+ TRM cells that responded to C albicans in an MHC class II-restricted fashion could be identified readily. CONCLUSIONS: These studies demonstrate that C albicans infection of skin preferentially generates CD4+ IL-17-producing TRM cells, which mediate durable protective immunity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piel / Candida albicans / Candidiasis / Subgrupos de Linfocitos T / Células Th17 Límite: Adult / Animals / Humans / Newborn Idioma: En Revista: J Allergy Clin Immunol Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piel / Candida albicans / Candidiasis / Subgrupos de Linfocitos T / Células Th17 Límite: Adult / Animals / Humans / Newborn Idioma: En Revista: J Allergy Clin Immunol Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos