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Imbalanced Osteogenesis and Adipogenesis in Mice Deficient in the Chemokine Cxcl12/Sdf1 in the Bone Mesenchymal Stem/Progenitor Cells.
Tzeng, Yi-Shiuan; Chung, Ni-Chun; Chen, Yu-Ren; Huang, Hsin-Yi; Chuang, Wen-Po; Lai, Dar-Ming.
Afiliación
  • Tzeng YS; Graduate Institute of Oncology, National Taiwan University College of Medicine, Taipei, Taiwan.
  • Chung NC; Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan.
  • Chen YR; Graduate Institute of Oncology, National Taiwan University College of Medicine, Taipei, Taiwan.
  • Huang HY; Department of Pathology, National Taiwan University Hospital, Taipei, Taiwan.
  • Chuang WP; Cardiovascular Center, Far Eastern Memorial Hospital, New Taipei City, Taiwan.
  • Lai DM; Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan.
J Bone Miner Res ; 33(4): 679-690, 2018 04.
Article en En | MEDLINE | ID: mdl-29120093
Bone and bone marrow serve as an imperative ecosystem to various types of cells participating in critical body functions. The chemokine Cxcl12, also known as stromal cell-derived factor 1 (Sdf1), is one of the communication factors in the marrow microenvironment that regulates hematopoietic stem/progenitor cell homeostasis. However, the function of Cxcl12 in other bone marrow cells in vivo is yet to be discovered. Here we report a novel function of Cxcl12 in postnatal bone development and homeostasis. Targeted deletion of Cxcl12 in Paired related homeobox 1 (Prx1)-expressing or osterix (Osx)-expressing mesenchymal stem/progenitor cells (MSPCs), but not in mature osteoblasts, resulted in marrow adiposity and reduced trabecular bone content. In vivo lineage tracing analysis revealed biased differentiation of MSPCs toward adipocytes. In contrast, adult-stage deletion of Cxcl12 in Osx-expressing cells led to reduced bone content but not adiposity. Targeting the receptor Cxcr4 in the Prx1-expressing cells also resulted in reduced trabecular bone content but not adiposity. Our study reveals a previously unidentified role of the MSPC-secreting Cxcl12 that regulates its osteogenesis and adipogenesis through the cell-autonomous and non-autonomous mechanism, respectively; which could further influence the homeostatic control of the hematopoietic system. © 2017 American Society for Bone and Mineral Research.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Osteoblastos / Osteogénesis / Células de la Médula Ósea / Adipogénesis / Quimiocina CXCL12 / Células Madre Mesenquimatosas Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Bone Miner Res Asunto de la revista: METABOLISMO / ORTOPEDIA Año: 2018 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Osteoblastos / Osteogénesis / Células de la Médula Ósea / Adipogénesis / Quimiocina CXCL12 / Células Madre Mesenquimatosas Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Bone Miner Res Asunto de la revista: METABOLISMO / ORTOPEDIA Año: 2018 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Estados Unidos