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The Role of Metabolite-Sensing G Protein-Coupled Receptors in Inflammation and Metabolic Disease.
Recio, Carlota; Lucy, Daniel; Iveson, Poppy; Iqbal, Asif J; Valaris, Sophia; Wynne, Graham; Russell, Angela J; Choudhury, Robin P; O'Callaghan, Chris; Monaco, Claudia; Greaves, David R.
Afiliación
  • Recio C; 1 Sir William Dunn School of Pathology, University of Oxford , Oxford, Great Britain .
  • Lucy D; 2 Department of Chemistry, University of Oxford , Oxford, Great Britain .
  • Iveson P; 1 Sir William Dunn School of Pathology, University of Oxford , Oxford, Great Britain .
  • Iqbal AJ; 1 Sir William Dunn School of Pathology, University of Oxford , Oxford, Great Britain .
  • Valaris S; 1 Sir William Dunn School of Pathology, University of Oxford , Oxford, Great Britain .
  • Wynne G; 2 Department of Chemistry, University of Oxford , Oxford, Great Britain .
  • Russell AJ; 2 Department of Chemistry, University of Oxford , Oxford, Great Britain .
  • Choudhury RP; 3 Radcliffe Department of Medicine, University of Oxford , Oxford, Great Britain .
  • O'Callaghan C; 4 Nuffield Department of Medicine, University of Oxford , Oxford, Great Britain .
  • Monaco C; 5 Kennedy Institute for Rheumatology, University of Oxford , Oxford, Great Britain .
  • Greaves DR; 1 Sir William Dunn School of Pathology, University of Oxford , Oxford, Great Britain .
Antioxid Redox Signal ; 29(3): 237-256, 2018 07 20.
Article en En | MEDLINE | ID: mdl-29117706
SIGNIFICANCE: Great attention has been placed on the link between metabolism and immune function giving rise to the term "immunometabolism." It is widely accepted that inflammation and oxidative stress are key processes that underlie metabolic complications during obesity, diabetes, and atherosclerosis. Therefore, identifying the mechanisms and mediators that are involved in the regulation of both inflammation and metabolic homeostasis is of high scientific and therapeutic interest. Recent Advances: G protein-coupled receptors (GPCRs) that signal in response to metabolites have emerged as attractive therapeutic targets in inflammatory disease. Critical Issues and Future Directions: In this review, we discuss recent findings about the physiological role of the main metabolite-sensing GPCRs, their implication in immunometabolic disorders, their principal endogenous and synthetic ligands, and their potential as drug targets in inflammation and metabolic disease. Antioxid. Redox Signal. 29, 237-256.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptores Acoplados a Proteínas G / Inflamación / Enfermedades Metabólicas Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Antioxid Redox Signal Asunto de la revista: METABOLISMO Año: 2018 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptores Acoplados a Proteínas G / Inflamación / Enfermedades Metabólicas Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Antioxid Redox Signal Asunto de la revista: METABOLISMO Año: 2018 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Estados Unidos