Your browser doesn't support javascript.
loading
Sex Differences in Trauma-Related Psychopathology: a Critical Review of Neuroimaging Literature (2014-2017).
Helpman, Liat; Zhu, Xi; Suarez-Jimenez, Benjamin; Lazarov, Amit; Monk, Catherine; Neria, Yuval.
Afiliación
  • Helpman L; Department of Psychiatry and the New York State Psychiatric Institute, Columbia University Medical Center, 1051 Riverside Dr. Unit no. 69, New York, NY, 10025, USA. liat.helpman@gmail.com.
  • Zhu X; Department of Psychiatry and the New York State Psychiatric Institute, Columbia University Medical Center, 1051 Riverside Dr. Unit no. 69, New York, NY, 10025, USA.
  • Suarez-Jimenez B; Department of Psychiatry and the New York State Psychiatric Institute, Columbia University Medical Center, 1051 Riverside Dr. Unit no. 69, New York, NY, 10025, USA.
  • Lazarov A; Department of Psychiatry and the New York State Psychiatric Institute, Columbia University Medical Center, 1051 Riverside Dr. Unit no. 69, New York, NY, 10025, USA.
  • Monk C; Department of Psychiatry and the New York State Psychiatric Institute, Columbia University Medical Center, 1051 Riverside Dr. Unit no. 69, New York, NY, 10025, USA.
  • Neria Y; Department of Psychiatry and the New York State Psychiatric Institute, Columbia University Medical Center, 1051 Riverside Dr. Unit no. 69, New York, NY, 10025, USA.
Curr Psychiatry Rep ; 19(12): 104, 2017 Nov 08.
Article en En | MEDLINE | ID: mdl-29116470
PURPOSE OF REVIEW: Sex differences in the epidemiology and clinical presentation of trauma-related psychopathology have long been documented. Multiple underlying mechanisms have been examined, both psychosocial and biological. Among the most promising biological mechanisms are neural substrates of trauma-related psychopathology that have been uncovered in recent years. RECENT FINDINGS: Neuroimaging studies of sex-related heterogeneity published over the past 3 years (2014-2017) demonstrate an interaction between sex and type, timing, and load of trauma exposure. These studies suggest that, for males, early trauma exposure may involve a loss of gray matter in the limbic system, including the prefrontal cortex (PFC), amygdala, and hippocampus, and an over-activity and increased connectivity of salience hubs, and particularly dorsal anterior cingulate cortex (dACC). For females, however, early trauma exposure may involve overactive and possibly an enlarged amygdala, as well as decreased connectivity of salience hubs such as the dACC. Underlying mechanisms may include interaction with several endocrine systems and result in differential neural response to naturally occurring and added endocrine ligands, as well as sex-specific genetic and epigenetic risk and resilience factors. This complex interaction between multiple biological systems may be associated with sex-specific behavioral patterns, in turn associated with trauma-related psychopathology. While substantial number of published studies present preliminary evidence for neural mechanisms of sex-specific posttraumatic responses, there is a paucity of research directly designed to examine sex as a biological factor in trauma-related psychopathology. Specific foci for future studies aiming to bridge current gaps in the literature are discussed.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Psicopatología / Caracteres Sexuales / Neuroimagen / Trauma Psicológico Límite: Female / Humans / Male Idioma: En Revista: Curr Psychiatry Rep Asunto de la revista: PSIQUIATRIA Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Psicopatología / Caracteres Sexuales / Neuroimagen / Trauma Psicológico Límite: Female / Humans / Male Idioma: En Revista: Curr Psychiatry Rep Asunto de la revista: PSIQUIATRIA Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos