Two tissue-specific factors bind the erythroid promoter of the human porphobilinogen deaminase gene.
Nucleic Acids Res
; 17(1): 37-54, 1989 Jan 11.
Article
en En
| MEDLINE
| ID: mdl-2911469
We have studied the erythroid-specific promoter of the human gene coding for Porphobilinogen Deaminase (PBGD) by DNaseI footprinting, gel retardation and methylation interference assays. We show that this promoter, which is inducible during MEL cell differentiation, contains three binding sites for the erythroid-specific factor NF-E1 and one site for a second erythroid-specific factor, which we name NF-E2. NF-E1 is a factor that also binds the promoter and the enhancer (present in the 3' flanking region) of the human beta-globin gene. NF-E2 has not yet been described and although it binds to a sequence containing the Ap1 consensus, it appears to be different from Ap1.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Hidroximetilbilano Sintasa
/
Regiones Promotoras Genéticas
/
Proteínas de Unión al ADN
/
Eritrocitos
/
Genes
/
Amoníaco-Liasas
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Nucleic Acids Res
Año:
1989
Tipo del documento:
Article
Pais de publicación:
Reino Unido