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A comparative study of neoadjuvant treatment with gemcitabine plus nab-paclitaxel versus surgery first for pancreatic adenocarcinoma.
Ielpo, Benedetto; Caruso, Riccardo; Duran, Hipolito; Diaz, Eduardo; Fabra, Isabel; Malavé, Luis; Ferri, Valentina; Alvarez, Rafael; Cubillo, Antonio; Plaza, Carlos; Lazzaro, Sara; Kalivaci, Denis; Quijano, Yolanda; Vicente, Emilio.
Afiliación
  • Ielpo B; General Surgery Department, Sanchinarro HM University Hospital, CEU San Pablo University of Madrid, Spain. Electronic address: ielpo.b@gmail.com.
  • Caruso R; General Surgery Department, Sanchinarro HM University Hospital, CEU San Pablo University of Madrid, Spain.
  • Duran H; General Surgery Department, Sanchinarro HM University Hospital, CEU San Pablo University of Madrid, Spain.
  • Diaz E; General Surgery Department, Sanchinarro HM University Hospital, CEU San Pablo University of Madrid, Spain.
  • Fabra I; General Surgery Department, Sanchinarro HM University Hospital, CEU San Pablo University of Madrid, Spain.
  • Malavé L; General Surgery Department, Sanchinarro HM University Hospital, CEU San Pablo University of Madrid, Spain.
  • Ferri V; General Surgery Department, Sanchinarro HM University Hospital, CEU San Pablo University of Madrid, Spain.
  • Alvarez R; General Surgery Department, Sanchinarro HM University Hospital, CEU San Pablo University of Madrid, Spain.
  • Cubillo A; General Surgery Department, Sanchinarro HM University Hospital, CEU San Pablo University of Madrid, Spain.
  • Plaza C; General Surgery Department, Sanchinarro HM University Hospital, CEU San Pablo University of Madrid, Spain.
  • Lazzaro S; General Surgery Department, Sanchinarro HM University Hospital, CEU San Pablo University of Madrid, Spain.
  • Kalivaci D; General Surgery Department, Sanchinarro HM University Hospital, CEU San Pablo University of Madrid, Spain.
  • Quijano Y; General Surgery Department, Sanchinarro HM University Hospital, CEU San Pablo University of Madrid, Spain.
  • Vicente E; General Surgery Department, Sanchinarro HM University Hospital, CEU San Pablo University of Madrid, Spain.
Surg Oncol ; 26(4): 402-410, 2017 Dec.
Article en En | MEDLINE | ID: mdl-29113659
INTRODUCTION: Neoadjuvant treatment has been reported to prolong survival in patients with potentially resectable pancreatic adenocarcinoma (PA). However, there are currently limited clinical results available using nab-paclitaxel and gemcitabine in PA. This paper compares the oncological results of patients affected by potentially resectable PA who underwent surgery first (SF) versus surgery following neoadjuvant treatment (NAT). METHODS: This is an observational, comparative study whereby data were abstracted from a prospective database of patients affected by PA from 2007 to 2016. RESULTS: We included a total of 81 patients (36 SF and 45 NAT) which resulted in being preoperatively similar. Among the NAT patients, treatment was well tolerated and the resection rate was 68.8% (31/45 patients). There was a trend towards a higher R1 resection rate in the SF group compared with the NAT (13.8% vs 3.2%; p = 0.1). Median overall survival in the resected NAT group was higher (30.6 vs 22.1 months; p = 0.04). In the borderline resectable group, overall survival was found to be four times higher compared with SF (43.6 versus 13.5 months; p = 0.001). CONCLUSIONS: These data suggest that neoadjuvant treatment with gemcitabine/nab-paclitaxel is a safe and effective option for potentially resectable PA compared with the SF approach.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pancreatectomía / Neoplasias Pancreáticas / Adenocarcinoma / Protocolos de Quimioterapia Combinada Antineoplásica / Terapia Neoadyuvante Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Surg Oncol Asunto de la revista: NEOPLASIAS Año: 2017 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pancreatectomía / Neoplasias Pancreáticas / Adenocarcinoma / Protocolos de Quimioterapia Combinada Antineoplásica / Terapia Neoadyuvante Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Surg Oncol Asunto de la revista: NEOPLASIAS Año: 2017 Tipo del documento: Article Pais de publicación: Países Bajos