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Sleep Apnea and Kidney Function Trajectory: Results From a 20-Year Longitudinal Study of Healthy Middle-Aged Adults.
Canales, Muna T; Hagen, Erika W; Barnet, Jodi H; Peppard, Paul E; Derose, Stephen F.
Afiliación
  • Canales MT; Department of Medicine, Malcom Randall VA Medical Center, University of Florida, Gainesville, FL.
  • Hagen EW; Department of Population Health Sciences, University of Wisconsin - Madison, Madison, WI.
  • Barnet JH; Department of Population Health Sciences, University of Wisconsin - Madison, Madison, WI.
  • Peppard PE; Department of Population Health Sciences, University of Wisconsin - Madison, Madison, WI.
  • Derose SF; Kaiser Permanente Southern California, Pasadena, CA.
Sleep ; 41(1)2018 01 01.
Article en En | MEDLINE | ID: mdl-29112764
Study Objectives: To determine whether sleep apnea, defined by polysomnography, accelerates kidney function decline in generally healthy adults not selected for sleep apnea or kidney disease. Methods: We performed a retrospective cohort study in 855 participants from the Wisconsin Sleep Cohort Study, a large 20-year population-based study of sleep apnea, who had at least one polysomnogram and serial measurements of serum creatinine over time. Sleep apnea was defined as an apnea-hypopnea index ≥ 15 or positive airway pressure (PAP) use at baseline. We compared the slope of estimated glomerular filtration rate (eGFR) change and odds of rapid eGFR decline (>2.2 mL/minute/1.73 m2/year) for those with and without sleep apnea. Results: The mean follow-up was 13.9 ± 3.4 years. The cohort was 50.4 ± 7.6 years, 55% male, and 97% white. The mean eGFR was 89.3 ± 13.8 mL/minute/1.73 m2 and 11% had sleep apnea. Overall, the mean eGFR change was -0.88 ± 1.12 mL/minute/1.73 m2/year. Compared with those without sleep apnea, participants with sleep apnea had a 0.2 mL/minute/1.73 m2/year slower eGFR decline though this was not statistically significant (95% CI [-0.06-0.45], p = .134). When we excluded those on PAP therapy (n = 17), eGFR decline was even slower among those with sleep apnea (0.36 mL/minute/1.73 m2/year slower, 95% CI [0.08-063], p = .012). Those with sleep apnea had lower odds of rapid eGFR decline but this was not statistically significant, even after excluding PAP users. Conclusion: Among healthy middle-aged adults, the presence of sleep apnea at baseline did not accelerate kidney function decline compared with those without sleep apnea over time.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sueño / Síndromes de la Apnea del Sueño / Tasa de Filtración Glomerular / Riñón Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: America do norte Idioma: En Revista: Sleep Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sueño / Síndromes de la Apnea del Sueño / Tasa de Filtración Glomerular / Riñón Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: America do norte Idioma: En Revista: Sleep Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos