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Efficient antibacterial nanosponges based on ZnO nanoparticles and doxycycline.
Suárez, Diego F; Monteiro, Ana P F; Ferreira, Daniele C; Brandão, Frederico D; Krambrock, Klaus; Modolo, Luzia V; Cortés, Maria E; Sinisterra, Rubén D.
Afiliación
  • Suárez DF; Chemistry Department, Universidade Federal de Minas Gerais, Belo Horizonte, MG CEP: 31270-901, Brazil.
  • Monteiro APF; Chemistry Department, Universidade Federal de Minas Gerais, Belo Horizonte, MG CEP: 31270-901, Brazil.
  • Ferreira DC; Physics Department, Universidade Federal de Minas Gerais, Belo Horizonte, MG CEP: 31270-901, Brazil.
  • Brandão FD; Physics Department, Universidade Federal de Minas Gerais, Belo Horizonte, MG CEP: 31270-901, Brazil.
  • Krambrock K; Physics Department, Universidade Federal de Minas Gerais, Belo Horizonte, MG CEP: 31270-901, Brazil.
  • Modolo LV; Department of Botany, Universidade Federal de Minas Gerais, Belo Horizonte, MG CEP: 31270-901, Brazil.
  • Cortés ME; Restorative Dentistry Department, Faculty of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, MG CEP: 31270-901, Brazil.
  • Sinisterra RD; Chemistry Department, Universidade Federal de Minas Gerais, Belo Horizonte, MG CEP: 31270-901, Brazil. Electronic address: sinisterra@ufmg.br.
J Photochem Photobiol B ; 177: 85-94, 2017 Dec.
Article en En | MEDLINE | ID: mdl-29107206
Bacterial soft rot is responsible for the loss of about 25% of worldwide production in vegetables and fruits. Efforts have been made to develop an effective nanosponge with the capacity to load and release antibacterial drugs to protect plants. Based on the potential of the ZnO nanoparticles (ZnO-NPs) to achieve this goal, this study synthesized NP via the sol-gel and hydrothermal methods by controlling native defects, such as oxygen vacancies, using thermal treatments and reduced atmospheres. To characterize the ZnO NPs, X-ray diffraction (XRD), Raman spectroscopy, transmission electron microscopy (TEM), optical spectroscopy, electron paramagnetic resonance (EPR), Zeta Potential measurements and surface area with the Brunauer-Emmett-Teller (BET) method were used. The photophysical and photochemical properties via spin trapping method aligned with EPR using UVA light showed a greater formation of electron-hole pairs and hydroxyl radicals for the reduced ZnO NPs when compared with the oxidized ones. Additionally, we found that reduced ZnO-NPs have high effectively against Escherichia coli, Erwinia carotovora and Pantoea sp. bacteria using the photocatalytic effect in the UV range. Moreover, ZnO-NPs loaded with DOX release profile enables the release of DOX within 46days, where 25% was released during the first 10h followed by a second delivery phase with an interesting short-term efficacy (<1day) against E. carotovora and Pantoea sp. Bacteria. For the first time, it was demonstrated that ZnO-NPs and ZnO-NPs loaded with DOX have efficient UV photocatalytic activities against bacterial soft rot infections.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Óxido de Zinc / Portadores de Fármacos / Doxiciclina / Nanopartículas del Metal / Antibacterianos Idioma: En Revista: J Photochem Photobiol B Asunto de la revista: BIOLOGIA Año: 2017 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Óxido de Zinc / Portadores de Fármacos / Doxiciclina / Nanopartículas del Metal / Antibacterianos Idioma: En Revista: J Photochem Photobiol B Asunto de la revista: BIOLOGIA Año: 2017 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Suiza