Doxorubicin induces ZAK&#945; overexpression with a subsequent enhancement of apoptosis and attenuation of survivability in human osteosarcoma cells.

Fu, Chien-Yao; Tseng, Yan-Shen; Chen, Ming-Cheng; Hsu, Hsi-Hsien; Yang, Jaw-Ji; Tu, Chuan-Chou; Lin, Yueh-Min; Viswanadha, Vijaya Padma; Kuo, Wei-Wen; Huang, Chih-Yang

Doxorubicin induces ZAKα overexpression with a subsequent enhancement of apoptosis and attenuation of survivability in human osteosarcoma cells.

Fu, Chien-Yao; Tseng, Yan-Shen; Chen, Ming-Cheng; Hsu, Hsi-Hsien; Yang, Jaw-Ji; Tu, Chuan-Chou; Lin, Yueh-Min; Viswanadha, Vijaya Padma; Kuo, Wei-Wen; Huang, Chih-Yang.

Afiliación

Fu CY; Graduate Institute of Aging Medicine, China Medical University, Taichung, Taiwan.
Tseng YS; Orthopaedic Department, Armed Forces General Hospital, Taichung, Taiwan.
Chen MC; Department of Orthopaedic, National Defense Medical Center, Taipei, Taiwan.
Hsu HH; Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan.
Yang JJ; Division of Colorectal Surgery, Department of Surgery, Taichung Veterans General Hospital, Taichung, 40705, Taiwan.
Tu CC; Division of Colorectal Surgery, Mackay Memorial Hospital, Taipei, 10449, Taiwan.
Lin YM; Nursing and Management College, Mackay Medicine, Taipei, 11260, Taiwan.
Viswanadha VP; School of Dentistry, Chung-Shan Medical University, Taichung, 402, Taiwan.
Kuo WW; Division of Chest Medicine, Department of Internal Medicine, Armed Force Taichung General Hospital, Taichung, 41152, Taiwan.
Huang CY; Department of Pathology, Changhua Christian Hospital, Changhua, 500, Taiwan.

Environ Toxicol ; 33(2): 191-197, 2018 Feb.

Article en En | MEDLINE | ID: mdl-29105997

Asunto(s)

Antibióticos Antineoplásicos/toxicidad; Apoptosis/efectos de los fármacos; Doxorrubicina/toxicidad; Proteínas Quinasas/metabolismo; Neoplasias Óseas/metabolismo; Neoplasias Óseas/patología; Caspasa 3/metabolismo; Línea Celular Tumoral; Proliferación Celular/efectos de los fármacos; Supervivencia Celular/efectos de los fármacos; Humanos; Quinasas Quinasa Quinasa PAM; FN-kappa B/metabolismo; Osteosarcoma/metabolismo; Osteosarcoma/patología; Proteínas Quinasas/química; Proteínas Quinasas/genética; Interferencia de ARN; ARN Interferente Pequeño/metabolismo; Proteína bcl-X/metabolismo

Palabras clave

ZAKα; apoptosis; doxorubicin; human osteosarcoma cells

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Quinasas / Doxorrubicina / Apoptosis / Antibióticos Antineoplásicos Límite: Humans Idioma: En Revista: Environ Toxicol Asunto de la revista: SAUDE AMBIENTAL / TOXICOLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Estados Unidos

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