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Secreted gelsolin desensitizes and induces apoptosis of infiltrated lymphocytes in prostate cancer.
Chen, Chun-Chi; Chiou, Shiow-Her; Yang, Cheng-Lin; Chow, Kuan-Chih; Lin, Tze-Yi; Chang, Hui-Wen; You, Weir-Chiang; Huang, Hisu-Wen; Chen, Chien-Min; Chen, Nien-Cheng; Chou, Fen-Pi; Chou, Ming-Chih.
Afiliación
  • Chen CC; Institute of Medicine, Chung-Shan Medical University, Taichung, Taiwan.
  • Chiou SH; Section of Urology, Departments of Surgery, Changhua Christian Hospital, Chang-Hua, Taiwan.
  • Yang CL; Graduate Institute of Microbiology and Public Health, National Chung Hsing University, Taichung, Taiwan.
  • Chow KC; Graduate Institute of Biomedical Sciences, National Chung Hsing University, Taichung, Taiwan.
  • Lin TY; Graduate Institute of Biomedical Sciences, National Chung Hsing University, Taichung, Taiwan.
  • Chang HW; Department of Pathology, China Medical University Hospital, China Medical University, Taichung, Taiwan.
  • You WC; Department of Pathology, China Medical University Hospital, China Medical University, Taichung, Taiwan.
  • Huang HW; Department of Radiation Oncology, Taichung Veterans General Hospital, Taichung, Taiwan.
  • Chen CM; Endemic Species Research Institute, Council of Agriculture, Executive Yuan, Chi-Chi, Taiwan.
  • Chen NC; Endemic Species Research Institute, Council of Agriculture, Executive Yuan, Chi-Chi, Taiwan.
  • Chou FP; Institute of Biochemistry, Microbiology and Immunology, Chung-Shan Medical University, Taichung, Taiwan.
  • Chou MC; Institute of Biochemistry, Microbiology and Immunology, Chung-Shan Medical University, Taichung, Taiwan.
Oncotarget ; 8(44): 77152-77167, 2017 Sep 29.
Article en En | MEDLINE | ID: mdl-29100377
Loss of immunosurveillance is a major cause of cancer progression. Here, we demonstrate that gelsolin, a constituent of ejaculate, induces apoptosis of activated lymphocytes in prostate cancer. Gelsolin was highly expressed in prostate cancer cells, and was associated with tumor progression, recurrence, metastasis, and poor prognosis. In vitro, secreted gelsolin inactivated CD4+ T cells by binding to CD37, and induced apoptosis of activated CD8+ T lymphocytes by binding to Fas ligand during cell contact dependent on major histocompatibility complex I. Moreover, secreted gelsolin bound to sortilin, which in turn bound to Wiskott-Aldrich syndrome protein family member 3, thereby enhancing the endocytosis and intracellular transport of essential lipids needed to facilitate tumor growth and expansion. Under normal conditions, gelsolin is a seemingly harmless protein that prevents immune responses in female recipients. In disease states, however, this protein can inhibit immunosurveillance and promote cancer progression.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Oncotarget Año: 2017 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Oncotarget Año: 2017 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Estados Unidos