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Interleukin-6 secreted by oral cancer- associated fibroblast accelerated VEGF expression in tumor and stroma cells.
Mirkeshavarz, M; Ganjibakhsh, M; Aminishakib, P; Farzaneh, P; Mahdavi, N; Vakhshiteh, F; Karimi, A; Gohari, N S; Kamali, F; Kharazifard, M J; Shahzadeh Fazeli, S A; Nasimian, A.
Afiliación
  • Mirkeshavarz M; Department of Oral and Maxillofacial Pathology, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
  • Ganjibakhsh M; Human and Animal cell Bank, Iranian Biological Resource Center (IBRC), ACECR, Tehran, Iran.
  • Aminishakib P; Dental Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
  • Farzaneh P; Human and Animal cell Bank, Iranian Biological Resource Center (IBRC), ACECR, Tehran, Iran.
  • Mahdavi N; Department of Oral and Maxillofacial Pathology, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
  • Vakhshiteh F; Human and Animal cell Bank, Iranian Biological Resource Center (IBRC), ACECR, Tehran, Iran.
  • Karimi A; Department of Oral and Maxillofacial Surgery, Craniomaxillofacial Research Center, Tehran University of Medical Sciences, Tehran, Iran.
  • Gohari NS; Human and Animal cell Bank, Iranian Biological Resource Center (IBRC), ACECR, Tehran, Iran.
  • Kamali F; Tumor Bank, Cancer Institute Hospital, Tehran University of Medical Sciences, Tehran, Iran.
  • Kharazifard MJ; Dental Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
  • Shahzadeh Fazeli SA; Human and Animal cell Bank, Iranian Biological Resource Center (IBRC), ACECR, Tehran, Iran.
  • Nasimian A; Human and Animal cell Bank, Iranian Biological Resource Center (IBRC), ACECR, Tehran, Iran.
Cell Mol Biol (Noisy-le-grand) ; 63(10): 131-136, 2017 Oct 31.
Article en En | MEDLINE | ID: mdl-29096753
Oral cancer represents the sixth most common cancer type worldwide. Patients with oral cancer express high levels of IL-6 which is associated with very poor prognosis. Previous studies illustrated that IL-6 cytokine induces angiogenesis. It has also been reported that the presence of Cancer- Associated Fibroblasts (CAFs) is essential for angiogenesis. In this study, we examined the correlation between IL-6 and CAF and the role of this correlation on VEGF production. In this study, quantitative expression level of IL-6 and VEGF in CAF and Oral Cancer Cells (OCCs) examined through Real Time PCR and ELISA and western blot analysis. In addition, maintenance and retention of IL-6 and VEGF checked out in co-culture experiment of CAF and OCC cells. These experiments demonstrated that in oral cancer, CAF cell line secretes significantly more IL-6 than OCC. Also IL-6 is a factor that causes VEGF secretion in CAF cell line. CAF is the basic and the most essential source for producing IL-6 in patients with oral cancer. Secreted IL-6 is able to induce VEGF production in both CAF and OCCs. Correlation between CAF, IL-6 and VEGF could be considered as an approach for cancer therapy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Interleucina-6 / Factor A de Crecimiento Endotelial Vascular Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans / Male / Middle aged Idioma: En Revista: Cell Mol Biol (Noisy-le-grand) Asunto de la revista: BIOLOGIA MOLECULAR Año: 2017 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Francia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Interleucina-6 / Factor A de Crecimiento Endotelial Vascular Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans / Male / Middle aged Idioma: En Revista: Cell Mol Biol (Noisy-le-grand) Asunto de la revista: BIOLOGIA MOLECULAR Año: 2017 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Francia