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Modification of the natural progression of epileptogenesis by means of biperiden in the pilocarpine model of epilepsy.
Bittencourt, Simone; Ferrazoli, Enéas; Valente, Maria Fernanda; Romariz, Simone; Janisset, Nilma R L L; Macedo, Carlos Eduardo; Antonio, Bruno de Brito; Barros, Vanessa; Mundim, Mayara; Porcionatto, Marimélia; Aarão, Mayra Consuelo; Miranda, Maísa Ferreira; Rodrigues, Antônio Márcio; de Almeida, Antônio-Carlos Guimarães; Longo, Beatriz M; Mello, Luiz E.
Afiliación
  • Bittencourt S; Departament of Physiology, Universidade Federal de São Paulo, São Paulo, SP 04039-032, Brazil.
  • Ferrazoli E; Departament of Physiology, Universidade Federal de São Paulo, São Paulo, SP 04039-032, Brazil.
  • Valente MF; Departament of Physiology, Universidade Federal de São Paulo, São Paulo, SP 04039-032, Brazil.
  • Romariz S; Departament of Physiology, Universidade Federal de São Paulo, São Paulo, SP 04039-032, Brazil.
  • Janisset NRLL; Departament of Physiology, Universidade Federal de São Paulo, São Paulo, SP 04039-032, Brazil.
  • Macedo CE; Departament of Physiology, Universidade Federal de São Paulo, São Paulo, SP 04039-032, Brazil.
  • Antonio BB; Departament of Psychobiology, Universidade Federal de São Paulo, São Paulo/SP 04039-032, Brazil.
  • Barros V; Departament of Physiology, Universidade Federal de São Paulo, São Paulo, SP 04039-032, Brazil.
  • Mundim M; Department of Biochemistry, Universidade Federal de São Paulo, São Paulo/SP 04039-032, Brazil.
  • Porcionatto M; Department of Biochemistry, Universidade Federal de São Paulo, São Paulo/SP 04039-032, Brazil.
  • Aarão MC; Departament of Biosystems Engineering, Universidade Federal de São João Del Rei, Minas Gerais, MG 36307-352, Brazil.
  • Miranda MF; Departament of Biosystems Engineering, Universidade Federal de São João Del Rei, Minas Gerais, MG 36307-352, Brazil.
  • Rodrigues AM; Departament of Biosystems Engineering, Universidade Federal de São João Del Rei, Minas Gerais, MG 36307-352, Brazil.
  • de Almeida AG; Departament of Biosystems Engineering, Universidade Federal de São João Del Rei, Minas Gerais, MG 36307-352, Brazil.
  • Longo BM; Departament of Physiology, Universidade Federal de São Paulo, São Paulo, SP 04039-032, Brazil.
  • Mello LE; Departament of Physiology, Universidade Federal de São Paulo, São Paulo, SP 04039-032, Brazil. Electronic address: lemello@unifesp.br.
Epilepsy Res ; 138: 88-97, 2017 12.
Article en En | MEDLINE | ID: mdl-29096134
Brain injuries are often associated with the later development of epilepsy. Evidence suggests that morphological and functional changes occur in the remaining neural tissue during a silent (or latent) period in which no seizures are expressed. It is believed that this silent (reorganization) period may provide a therapeutic window for modifying the natural history of disease progression. Here we provide evidence that biperiden, a muscarinic anticholinergic agent, is able to alter disease progression in an animal model of epilepsy. We observed that biperiden was capable of slowing the manifestation of the first spontaneous epileptic seizure and effectively reduced the severity and number of recurrent, spontaneous epileptic seizures during the animals' lifespan. Biomolecular (microdialysis) and electrophysiological (extracellular field recordings) studies determined that biperiden was capable of elevating the threshold of hippocampal excitability, thereby making the hippocampal glutamatergic pathways less responsive to stimuli when high concentrations of potassium were used in vivo or in vitro. Notably, there was no hindrance of long-term memory or learning (a potential problem given the amnestic nature of biperiden). We conclude that biperiden has antiepileptogenic potential and may represent an opportunity for the prevention of post-traumatic epilepsy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pilocarpina / Biperideno / Antagonistas Muscarínicos / Agonistas Muscarínicos / Epilepsia Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Epilepsy Res Asunto de la revista: CEREBRO / NEUROLOGIA Año: 2017 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pilocarpina / Biperideno / Antagonistas Muscarínicos / Agonistas Muscarínicos / Epilepsia Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Epilepsy Res Asunto de la revista: CEREBRO / NEUROLOGIA Año: 2017 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Países Bajos