Analgesic activities of crude ethanolic extract and various fractions of Adansonia digitata L. grown at the sindh province of Pakistan.
Pak J Pharm Sci
; 30(5): 1657-1663, 2017 Sep.
Article
en En
| MEDLINE
| ID: mdl-29084687
The current study aimed to evaluate the analgesic effects of crude extract and fractions of leaves of Adansonia digitata L. (Malvaceae). Fresh leaves were collected, dried under shade and then powdered. Moreover, powder was usedto extract with Ethanol and concentrated under reduced pressure, followed by partitioning with organic solvents i.e. Hexane, Ethylacetate, Butanol and Aqueous. These fractions were analyzed for analgesic effect at dose of 50, 100, 200; mg/kg body weight by acetic acid induced writhing, tail flick and hot plate analgesic models. No acute oral toxicity was observed and extracts considered being saved at a dose of 50-3000 mg/kg body weight. Orally administered extract of A. digitata showed analgesic activity described by decrease in writhes counts which was contrast to control. Significant (P<0.05-0.001) increased in latency period in hot plate analgesic test when compared Diclofenac sodium (50 mg/kg) which is used as a standard drug. Furthermore, in tail flick test a dose of (50, 100, 200mg/kg body weight) of extracts exhibited significant (P<0.05-0.001) analgesia which is dose dependent when compared to control group. These findings of analgesic testing have revealed that leaves extract of this nutritional plants possess remarkable antinociceptive effect.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Dolor
/
Solventes
/
Extractos Vegetales
/
Adansonia
/
Etanol
/
Analgésicos
Tipo de estudio:
Prognostic_studies
Límite:
Animals
País/Región como asunto:
Asia
Idioma:
En
Revista:
Pak J Pharm Sci
Asunto de la revista:
FARMACIA
/
FARMACOLOGIA
/
QUIMICA
Año:
2017
Tipo del documento:
Article
País de afiliación:
Pakistán
Pais de publicación:
Pakistán