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Role of GAD peptides p217 and p290 in the repair of INS receptor in salivary tissues of type 1 diabetic mice.
da Silva, Rodrigo Eduardo; Cervigne, Nilva de Karla; Pinto, Clovis Antonio Lopes; da Cunha, Marcelo Rodrigues; Rojas, Fernanda; Peroni, Luis Antonio; Augusto, Taize Machado; Marchi, Evaldo; Khan, Barkat Ali; Caldeira, Eduardo José.
Afiliación
  • da Silva RE; Tissue Morphology Laboratory, Department of Morphology and Basic Pathology, Faculty of Medicine of Jundiaí, São Paulo, Brazil.
  • Cervigne NK; Tissue Morphology Laboratory, Department of Morphology and Basic Pathology, Faculty of Medicine of Jundiaí, São Paulo, Brazil.
  • Pinto CAL; Pathology Laboratory, Department of Morphology and Basic Pathology, Faculty of Medicine of Jundiaí, Jundiaí, São Paulo, Brazil.
  • da Cunha MR; Tissue Morphology Laboratory, Department of Morphology and Basic Pathology, Faculty of Medicine of Jundiaí, São Paulo, Brazil.
  • Rojas F; Tissue Morphology Laboratory, Department of Morphology and Basic Pathology, Faculty of Medicine of Jundiaí, São Paulo, Brazil.
  • Peroni LA; Tissue Morphology Laboratory, Department of Morphology and Basic Pathology, Faculty of Medicine of Jundiaí, São Paulo, Brazil.
  • Augusto TM; Tissue Morphology Laboratory, Department of Morphology and Basic Pathology, Faculty of Medicine of Jundiaí, São Paulo, Brazil.
  • Marchi E; Surgery Department, Medical College of Jundiaí, FMJ, Jundiaí, São Paulo, Brazil.
  • Khan BA; Surgery Department, Medical College of Jundiaí, FMJ, Jundiaí, São Paulo, Brazil / Faculty of Pharmacy, Gomal University, D.I Khan, KPK, Pakistan.
  • Caldeira EJ; Tissue Morphology Laboratory, Department of Morphology and Basic Pathology, Faculty of Medicine of Jundiaí, São Paulo, Brazil.
Pak J Pharm Sci ; 30(5): 1545-1550, 2017 Sep.
Article en En | MEDLINE | ID: mdl-29084671
Glutamate decarboxylase or glutamic acid decarboxylase (GAD) is a protein associated with autoimmune diseases, including type-1 diabetes. This disease is primarily associated with the occurrence of a specific isoform: GAD65. Conversely, some specific peptides of this protein may block autoimmunity in diabetes. In this respect, understanding the relationship between GAD and the development of diabetes is important, and it is necessary to understand the role of each GAD peptide to design effective autoimmune diabetes treatments. The purpose of the present study was to analyze the effects of treatment with GAD-derived peptides p217 and p290 on INS receptors in the salivary epithelium of nonobese diabetic (NOD) animals. Three groups of 7 mice each were studied: I, BALB/c mice (control); II, NOD mice; and III, NOD mice treated with peptides p290 and p217. Groups I and II only received buffered saline solution. Glucose levels were measured daily during the 21 days of the experiment. After the study, the animals were euthanized and the parotid and submandibular glands were removed for the analysis of INS-R by fluorescence microscopy. Therapy with two peptides together was associated with reduced glucose levels in NOD mice and intense INS-R expression in both salivary organs. Our approach of combining GAD p217 and p290 peptides contributed to hormonal balance and promoted the repair of INS-R.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glándula Parótida / Fragmentos de Péptidos / Glándula Submandibular / Receptor de Insulina / Diabetes Mellitus Tipo 1 / Células Epiteliales / Glutamato Descarboxilasa / Hipoglucemiantes Límite: Animals Idioma: En Revista: Pak J Pharm Sci Asunto de la revista: FARMACIA / FARMACOLOGIA / QUIMICA Año: 2017 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Pakistán
Buscar en Google
Añadir a Mi BVS
Imprimir
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PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glándula Parótida / Fragmentos de Péptidos / Glándula Submandibular / Receptor de Insulina / Diabetes Mellitus Tipo 1 / Células Epiteliales / Glutamato Descarboxilasa / Hipoglucemiantes Límite: Animals Idioma: En Revista: Pak J Pharm Sci Asunto de la revista: FARMACIA / FARMACOLOGIA / QUIMICA Año: 2017 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Pakistán